氧化锌纳米颗粒对小鼠肾功能的影响

A. Noori, F. Karimi
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引用次数: 23

摘要

背景:考虑到氧化锌纳米颗粒的医学应用,评估其对生物体的不良影响是重要的。材料与方法:本研究采用单次注射氧化锌纳米颗粒(50、100、200、300mg/kg)对大鼠肾脏参数(尿酸、肌凝素、尿素)的影响。结果:结果显示,注射后8天,300 mg/kg组的尿素和肌酐水平显著升高(P)。结论:单次注射氧化锌纳米颗粒,特别是高剂量(300 mg/kg),对肾功能有短期影响(8天),但一个月后,可能随着纳米颗粒进入肾脏的逐渐消除,这些影响就消失了。然而,更多注射的进一步研究是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of zinc oxide nanoparticles on renal function in mice
Background: Considering the medical applications of zinc oxide nanoparticles, evaluating their adverse effects on the organisms is important. Materials and Methods: In this study, the effect of a single injection (ip) of zinc oxide nanoparticles (50, 100, 200, 300mg/kg) on changes in the renal parameters (uric acid, creatinin, urea) was studied after 8 and 30 days of the treatment. Results: Results showed that the urea and creatinine levels in the 300 mg/kg group were significantly increased 8 days after the injection (P Conclusion: It seems that a single injection of zinc oxide nanoparticles, especially at high doses (300 mg/kg), has a short-term effect (8 days) on the renal function, but after a month, possibly with the gradual elimination of nanoparticles uptake into the kidney, these effects disappear. However, further studies with more injections are essential.
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