头孢克肟、奥硝唑的对比联合高效液相色谱方法

S. Sharma
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引用次数: 0

摘要

头孢克肟是一种口服第三代头孢菌素类抗生素。用于治疗淋病、扁桃体炎和咽炎。本发明的色谱法用于测定原料药和制剂剂型中的三水合头孢克肟和奥硝唑。色谱柱为ACEC 18, 5μm,150 × 4.6 mm。将三水合头孢克肟和奥硝唑分别置于酸性、碱性、氧化性、中性、热和光解应激条件下,并对应激样品进行分析。三水合头孢克肟浓度在10 60 μg / mL范围内线性良好,相关系数为0.998;奥硝唑浓度在25 150 μg / mL范围内线性良好,相关系数为0.998;两种分析物的日内精密度和准确度均小于2% RSD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative & Combine HPLC Method of Development of Drugs and Validation of Cefixime & Ornidazole
Abstract – Cefixime is an oral third-generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsillitis and pharyngitis. The chromatography of the present invention is used to determine Cefixime trihydrate and Ornidazole in bulk drugs and pharmaceutical dosage forms. Separation and quantification were achieved on ACEC 18, 5μm,150 x 4.6 mm i. d. column. The Cefixime trihydrate and Ornidazole were exposed to acidic, basic, oxidative, neutral, thermal, and photolytic stress conditions, and stress samples were analyzed. The linearity of the Cefixime trihydrate concentration in the range of 10 60 μg / mL was good, the correlation coefficient was 0.998, the Ornidazole correlation coefficient was 0.998, 25 150 μg / mL, and the correlation coefficient was 0.997. The intraday precision and accuracy of both analytes were less than 2% RSD.
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