比较锂与丙戊酸钠对双相情感障碍患者发作间期临床和社会地位的影响:一项回顾性比较研究

A. Mowla, Sanaz Boostani, Zahra Ehsaei
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引用次数: 0

摘要

背景:我们的目的是比较丙戊酸钠与锂在延长双相情感障碍(BD) 1型患者情绪发作复发时间方面的疗效。还比较了发作间期患者的社会和职业功能。方法:对我院精神科324例躁狂期双相障碍患者的既往精神病史进行调查。如果患者从过去的情绪发作到现在的情绪发作一直坚持服用情绪稳定药物,他们就会进入研究。入院时共169例患者使用锂(平均剂量:785.7 mg), 155例患者使用丙戊酸钠(平均剂量:734.3 mg)。比较两组患者处于发作间期的时间。并比较发作间期患者的职业功能和社会功能。结果:锂盐组的发作间隔为28.7个月,丙戊酸钠组的发作间隔为29.4个月。两组在这方面差异无统计学意义(P = 0.564)。此外,药物滥用率(0.561)、离婚率(0.543)、自杀企图率(0.693)和失业率(P = 0.453)在发作间隔内锂组和丙戊酸组之间没有显著差异。结论:丙戊酸钠在预防双相患者情绪发作复发方面与锂同样有效。我们的患者在发作间期也表现出相当的职业和社会地位。J Neurol Res. 2020;000(000):000-000 doi: https://doi.org/10.14740/jnr610
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparing Lithium With Valproate for Clinical and Social Status of Bipolar Disorder Patients in Inter-Episode Interval: A Retrospective Comparative Study
Background: Our aim was to compare the efficacy of Na valproate with lithium in prolonging the time to mood episode recurrence in patients suffering from bipolar disorder (BD) type 1. Patients’ social and occupational functioning in the inter-episode interval was also compared. Methods: A total of 324 patients that were admitted in our psychiatry ward with diagnosis of BD, manic phase, were surveyed for their past psychiatry history. The patients entered the study if they had adhered to their mood stabilizing medications from their past mood episode till this current mood episode. A total of 169 patients were on lithium (mean dose: 785.7 mg) and 155 patients were on Na valproate (mean dose: 734.3 mg) while admitted. The time period the patients were in the inter-episode interval was compared between the two groups. The patients’ occupational and social functioning in the inter-episode interval was also compared. Results: The inter-episode interval was 28.7 months in the patients taking lithium and 29.4 months in the patients on Na valproate. There was no significant difference in this regard between the two groups (P = 0.564). Furthermore, rates of substance abuse (0.561), divorce (0.543), suicidal attempt (0.693) and unemployment (P = 0.453) in the inter-episode interval did not differ significantly between the lithium and valproate groups. Conclusions: Na valproate was demonstrated to be as effective as lithium in preventing mood episode recurrence in bipolar patients. Our patients also demonstrated comparable occupational and social status in the inter-episode interval. J Neurol Res. 2020;000(000):000-000 doi: https://doi.org/10.14740/jnr610
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