{"title":"持续选择性动脉注射抗生素治疗下颌骨放射性骨坏死","authors":"Masashi Shiiba , Yosuke Sakamoto , Toru Tsurumi , Ryuji Namba , Masakazu Akiba , Ken Shimada , Kenshi Kawasaki , Atsushi Kasamatsu , Kanae Ono , Katsunori Ogawara , Katsuhiro Uzawa , Hideki Tanzawa","doi":"10.1016/j.ajoms.2009.11.007","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study was performed to evaluate the usefulness of continuous-selective intra-arterial injection of antibiotics via the superior thyroid artery for osteoradionecrosis of the mandible.</p></div><div><h3>Patients and methods</h3><p>Three osteoradionecrosis cases were treated with this innovative drug delivery system. Totals of 7200<!--> <!-->mg, 7810<!--> <!-->mg and 6960<!--> <!-->mg of clindamycin (CLDM) were administered in cases 1, 2 and 3, respectively. Patients also received conventional intravenous cefozopran hydrochloride (CZOP) or ceftazidime (CAZ) or moxifloxacin (MFLX) and hyperbaric oxygen therapy (HBO).</p></div><div><h3>Results</h3><p>Both clinical findings and laboratory data improved immediately after these treatments in these cases.</p></div><div><h3>Conclusion</h3><p>The present study indicates that continuous-selective antibiotic injection via the superior thyroid artery might be an additional treatment option if performed in combination with conventional approaches in the refractory cases.</p></div>","PeriodicalId":100128,"journal":{"name":"Asian Journal of Oral and Maxillofacial Surgery","volume":"22 2","pages":"Pages 112-116"},"PeriodicalIF":0.0000,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ajoms.2009.11.007","citationCount":"0","resultStr":"{\"title\":\"Continuous-selective intra-arterial injection of antibiotics for osteoradionecrosis of the mandible\",\"authors\":\"Masashi Shiiba , Yosuke Sakamoto , Toru Tsurumi , Ryuji Namba , Masakazu Akiba , Ken Shimada , Kenshi Kawasaki , Atsushi Kasamatsu , Kanae Ono , Katsunori Ogawara , Katsuhiro Uzawa , Hideki Tanzawa\",\"doi\":\"10.1016/j.ajoms.2009.11.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>This study was performed to evaluate the usefulness of continuous-selective intra-arterial injection of antibiotics via the superior thyroid artery for osteoradionecrosis of the mandible.</p></div><div><h3>Patients and methods</h3><p>Three osteoradionecrosis cases were treated with this innovative drug delivery system. Totals of 7200<!--> <!-->mg, 7810<!--> <!-->mg and 6960<!--> <!-->mg of clindamycin (CLDM) were administered in cases 1, 2 and 3, respectively. Patients also received conventional intravenous cefozopran hydrochloride (CZOP) or ceftazidime (CAZ) or moxifloxacin (MFLX) and hyperbaric oxygen therapy (HBO).</p></div><div><h3>Results</h3><p>Both clinical findings and laboratory data improved immediately after these treatments in these cases.</p></div><div><h3>Conclusion</h3><p>The present study indicates that continuous-selective antibiotic injection via the superior thyroid artery might be an additional treatment option if performed in combination with conventional approaches in the refractory cases.</p></div>\",\"PeriodicalId\":100128,\"journal\":{\"name\":\"Asian Journal of Oral and Maxillofacial Surgery\",\"volume\":\"22 2\",\"pages\":\"Pages 112-116\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ajoms.2009.11.007\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Oral and Maxillofacial Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0915699210000464\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Oral and Maxillofacial Surgery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0915699210000464","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Continuous-selective intra-arterial injection of antibiotics for osteoradionecrosis of the mandible
Objective
This study was performed to evaluate the usefulness of continuous-selective intra-arterial injection of antibiotics via the superior thyroid artery for osteoradionecrosis of the mandible.
Patients and methods
Three osteoradionecrosis cases were treated with this innovative drug delivery system. Totals of 7200 mg, 7810 mg and 6960 mg of clindamycin (CLDM) were administered in cases 1, 2 and 3, respectively. Patients also received conventional intravenous cefozopran hydrochloride (CZOP) or ceftazidime (CAZ) or moxifloxacin (MFLX) and hyperbaric oxygen therapy (HBO).
Results
Both clinical findings and laboratory data improved immediately after these treatments in these cases.
Conclusion
The present study indicates that continuous-selective antibiotic injection via the superior thyroid artery might be an additional treatment option if performed in combination with conventional approaches in the refractory cases.
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