热浸提物减少甲基乙二醛诱导的人脐静脉内皮细胞晚期糖基化终产物的形成

Q3 Agricultural and Biological Sciences

Fisheries and Aquatic Sciences Pub Date : 2022-10-01 DOI:10.47853/fas.2022.e46

Seon-Heui Cha, H. Jun

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引用次数: 0

摘要

甲基乙二醛(MGO)是一种高活性的二羰基化合物，其过量产生与进行性糖尿病伴血管并发症有关。因此，我们研究了白榄肉热水提取物(LBM-HWE)是否对氧化镁诱导的人脐静脉内皮细胞(HUVECs)损伤具有保护作用。LBM-HWE提取物显示出抑制mgo诱导的细胞毒性。此外，LBM-HWE降低了促炎细胞因子的mRNA表达，减少了氧化石墨烯诱导的晚期糖基化终产物(AGEs)的形成。此外，LBM-HWE诱导了huvec中glyoxalase-1 mRNA的表达，并减少了mgo诱导的羰基蛋白的形成。结果提示，LBM-HWE通过阻止AGEs的形成，对mgo诱导的HUVECs毒性具有保护作用。综上所述，LBM-HWE可作为预防糖尿病血管并发症的潜在治疗材料。

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Hot water extract of Loliolus beka attenuates methylglyoxal-induced advanced glycation end products formation in human umbilical vein endothelial cells

Over production of methylglyoxal (MGO) a highly reactive dicarbonyl compound, has been associated in progressive diabetes with vascular complication. Therefore, we investigated whether hot water extract of Loliolus beka meat (LBM-HWE) presents a preserve effect against MGO-induced cellular damage in human umbilical vein endothelial cells (HUVECs). The LBM-HWE extract showed to inhibit MGO-induced cytotoxicity. Additionally, the LBM-HWE reduced mRNA expression of pro-inflammatory cytokines, and reduced MGO-induced advanced glycation end product (AGEs) formation. Furthermore, LBM-HWE induced glyoxalase-1 mRNA expression and reduced MGO-induced carbonyl protein formation in HUVECs. The results implicate that LBM-HWE has protective ability against MGO-induced HUVECs toxicity by preventing AGEs formation. In conclusion, LBM-HWE could be used as a potential treatment material for the prevention of vascular complications of diabetes.

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来源期刊

Fisheries and Aquatic Sciences Earth and Planetary Sciences-Oceanography

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

6 weeks