{"title":"Bp16524和Su 2242对伯格氏疟原虫的抗疟原虫活性研究","authors":"I. Ononiwu, B. Uko","doi":"10.4314/WAJPDR.V22I1.14768","DOIUrl":null,"url":null,"abstract":"The effects of two potential drug candidates: BP16524 [a synthetic analogue of cryptolepine] and SU 2242 [an enriched methanolic extract from Enantia chlorantha] on Plasmodium berghei were evaluated in this study. Investigations were performed using suppressive (early infection) and curative (established infection) test procedures. BP16524 showed significant dose dependent suppressive activity but was not effective against established infection. Significant (p Keywords : BP16524, SU 2242, Plasmodium berghei , early and established infections West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 51-54","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"16 1","pages":"51-54"},"PeriodicalIF":0.0000,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antiplasmodial Activity of Bp16524 and Su 2242 Against Plasmodium berghei\",\"authors\":\"I. Ononiwu, B. Uko\",\"doi\":\"10.4314/WAJPDR.V22I1.14768\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effects of two potential drug candidates: BP16524 [a synthetic analogue of cryptolepine] and SU 2242 [an enriched methanolic extract from Enantia chlorantha] on Plasmodium berghei were evaluated in this study. Investigations were performed using suppressive (early infection) and curative (established infection) test procedures. BP16524 showed significant dose dependent suppressive activity but was not effective against established infection. Significant (p Keywords : BP16524, SU 2242, Plasmodium berghei , early and established infections West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 51-54\",\"PeriodicalId\":23624,\"journal\":{\"name\":\"West African journal of pharmacology and drug research\",\"volume\":\"16 1\",\"pages\":\"51-54\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"West African journal of pharmacology and drug research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/WAJPDR.V22I1.14768\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"West African journal of pharmacology and drug research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/WAJPDR.V22I1.14768","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本研究评估了两种潜在的候选药物BP16524(隐tolepine的合成类似物)和SU 2242(绿刺苋的浓缩甲醇提取物)对伯氏疟原虫的作用。采用抑制性(早期感染)和治疗性(已确定感染)试验程序进行调查。BP16524表现出明显的剂量依赖性抑制活性，但对已建立的感染无效。关键词:BP16524, SU 2242，伯氏疟原虫，早期和建立感染西非药理学与药物研究Vol 22/23 2007: pp. 51-54
Antiplasmodial Activity of Bp16524 and Su 2242 Against Plasmodium berghei
The effects of two potential drug candidates: BP16524 [a synthetic analogue of cryptolepine] and SU 2242 [an enriched methanolic extract from Enantia chlorantha] on Plasmodium berghei were evaluated in this study. Investigations were performed using suppressive (early infection) and curative (established infection) test procedures. BP16524 showed significant dose dependent suppressive activity but was not effective against established infection. Significant (p Keywords : BP16524, SU 2242, Plasmodium berghei , early and established infections West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 51-54
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