基于单次后向散射偏振光谱的上皮组织异常分析

Yongqiang Zhao, PeiFeng Wei
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引用次数: 0

摘要

皮肤的病理变化会改变组织的双折射和结构,这可以通过组织散射光的偏振和光谱变化来测量。光散射偏振光谱是定量病理分析中测量这些特征的有效工具。本文建立了基于Mie理论的单后向散射光谱理论模型,用于描述双层散射介质的偏振光散射光谱。为了验证该模型的有效性,提出了一种上皮组织偏振光谱成像系统,并利用该系统对人体冻伤样本进行了成像。该模型用于获取与生物组织异常密切相关的形态学参数,包括平均直径、尺寸分布和相对折射率。实验结果证明了该技术在皮肤病理诊断和治疗评价方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epithelial Tissue Abnormity Analysis Based on Single Backscattering Polarimetric Spectrum
The pathological changes of skin will change the tissue's birefringence and structure, which can be measured by the polarization and spectral changes of tissue's scattering light. Light-scattering polarimetric spectrum is an effective tool to measure these features for quantitative pathology analysis. In this paper, a theoretical model of single backscattering spectra based on Mie theory is established, to describe the polarized light scattering spectroscopy for a two-layered scattering medium. To test the utility of this model, an epithelial tissue polarimetric spectral imaging system is proposed, then human frostbite sample is imaged using the system. Proposed model is used to acquire the morphological parameters closely relating to the abnormality of biological tissue, including the mean diameter, size distribution and relative refractive index. Experimental results demonstrated the potentials of the proposed techniques in skin pathological diagnosis and treatment evaluation.
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