{"title":"暴露于亚致死和亚慢性剂量乐果的小鼠血液学和免疫学参数的评价","authors":"A. Bhatia, J. Kaur","doi":"10.1080/10769180052008887","DOIUrl":null,"url":null,"abstract":"Effects of sublethal and subchronic doses of dimethoate (DM), an organophosphorus pesticide, have been studied on hematological and immunological parameters in mice. The results revealed that DM-treated mice showed significant increase in red blood cells (RBC), white blood cells, percent monocytes, and percent basophils, whereas the percent neutrophils was significantly decreased.The antibody titres were higher on day 4 postantigen(sheep RBC/bovine serum albumin [BSA]) inoculation, but suppressed on day 7 and 11 postantigen inoculation in DM-treated mice. However, the three cell-mediated immune parameters-leukocyte migration inhibition (LMI), leukocyte adherence inhibition (LAI), and nitroblue tetrazolium (NBT) reduction-were invariably depressed in DM-treated BSA-immunized mice, whereas the percent LMI and LAI were lower and NBT was higher in the DM-treated SRBC-immunized mice. Our results show that exposure to DM suppresses humoral and cell-mediated immune response, but its effect on macrophage function varies with the immunizing antigen.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"EVALUATION OF HEMATOLOGICAL AND IMMUNOLOGICAL PARAMETERS IN MICE EXPOSED TO SUBLETHAL AND SUBCHRONIC DOSES OF DIMETHOATE\",\"authors\":\"A. Bhatia, J. Kaur\",\"doi\":\"10.1080/10769180052008887\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Effects of sublethal and subchronic doses of dimethoate (DM), an organophosphorus pesticide, have been studied on hematological and immunological parameters in mice. The results revealed that DM-treated mice showed significant increase in red blood cells (RBC), white blood cells, percent monocytes, and percent basophils, whereas the percent neutrophils was significantly decreased.The antibody titres were higher on day 4 postantigen(sheep RBC/bovine serum albumin [BSA]) inoculation, but suppressed on day 7 and 11 postantigen inoculation in DM-treated mice. However, the three cell-mediated immune parameters-leukocyte migration inhibition (LMI), leukocyte adherence inhibition (LAI), and nitroblue tetrazolium (NBT) reduction-were invariably depressed in DM-treated BSA-immunized mice, whereas the percent LMI and LAI were lower and NBT was higher in the DM-treated SRBC-immunized mice. Our results show that exposure to DM suppresses humoral and cell-mediated immune response, but its effect on macrophage function varies with the immunizing antigen.\",\"PeriodicalId\":87425,\"journal\":{\"name\":\"Toxic substance mechanisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxic substance mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/10769180052008887\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10769180052008887","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
EVALUATION OF HEMATOLOGICAL AND IMMUNOLOGICAL PARAMETERS IN MICE EXPOSED TO SUBLETHAL AND SUBCHRONIC DOSES OF DIMETHOATE
Effects of sublethal and subchronic doses of dimethoate (DM), an organophosphorus pesticide, have been studied on hematological and immunological parameters in mice. The results revealed that DM-treated mice showed significant increase in red blood cells (RBC), white blood cells, percent monocytes, and percent basophils, whereas the percent neutrophils was significantly decreased.The antibody titres were higher on day 4 postantigen(sheep RBC/bovine serum albumin [BSA]) inoculation, but suppressed on day 7 and 11 postantigen inoculation in DM-treated mice. However, the three cell-mediated immune parameters-leukocyte migration inhibition (LMI), leukocyte adherence inhibition (LAI), and nitroblue tetrazolium (NBT) reduction-were invariably depressed in DM-treated BSA-immunized mice, whereas the percent LMI and LAI were lower and NBT was higher in the DM-treated SRBC-immunized mice. Our results show that exposure to DM suppresses humoral and cell-mediated immune response, but its effect on macrophage function varies with the immunizing antigen.