Prader-Willi综合征患者感觉加工与自闭症谱系障碍样行为的关系

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-04-20 DOI:10.1352/1944-7558-127.3.249

Sohei Saima, H. Ihara, Hiroyuki Ogata, Masao Gito, N. Murakami, Y. Oto, Atsushi Ishii, Asami Takahashi, T. Nagai

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引用次数: 0

摘要

Prader-Willi综合征(PWS)患者的感觉加工与asd样行为及相关行为之间的关系仍相对未被探索。研究人员对51名成年PWS患者进行了广泛性发育障碍自闭症协会评定量表(PARS)、短感觉量表(SSP-J)、食物相关问题问卷(FRPQ)和异常行为量表(ABC-J)。根据SSP-J - z评分，将参与者分为三个严重程度组。对三组的行为评分进行方差分析比较。PARS评分(p = 0.006， ηp2 = 0.194)和ABC-J评分(p = 0.006， ηp2 = 0.193)组间差异有统计学意义。我们的研究结果表明，感觉加工水平可以预测成年PWS患者的asd样行为和异常行为，这意味着对早期干预进行适当评估的重要性。

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Relationship Between Sensory Processing and Autism Spectrum Disorder-Like Behaviors in Prader-Willi Syndrome.

The relationship between sensory processing and ASD-like and associated behaviors in patients with Prader-Willi Syndrome (PWS) remains relatively unexplored. Examining this relationship, 51 adults with PWS were administered the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS), Short Sensory Profile (SSP-J), Food-Related Problem Questionnaire (FRPQ), and Aberrant Behavior Checklist (ABC-J). Based on SSP-J z-scores, participants were classified into three severity groups. Analysis of variance was performed to compare the behavioral scores of these three groups. Statistically significant group differences were observed in PARS (p = .006, ηp2 = .194) and ABC-J (p = .006, ηp2 = .193) scores. Our findings suggest that the level of sensory processing may predict ASD-like and aberrant behaviors in adults with PWS, implying the importance of a proper assessment for early intervention.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.