{"title":"饲粮中添加吡嗪酰胺对饲喂无烟酸限色氨酸断奶大鼠生长的影响","authors":"K. Shibata","doi":"10.1271/BBB1961.55.3111","DOIUrl":null,"url":null,"abstract":"Pyrazinamide is a strong inhibitor of aminocarboxymuconate semialdehyde decarboxylase (ACMSDase; EC 4.1.1.45) in vivo,1] which activity is thought to be critical in tryptophan-nicotinamide conversion.2 ~ 5) I reported that an intraperitoneal injection of pyrazinamide to rats fed with a nicotinic acid-free and 20% casein diet greatly increased urinary excretion of nicotinamide and its catabolic metabolites such as A^-methylnicotinamide (MNA), ^V 1-methyl-2-pyridone-5-carboxamide (2-Py), and Table I. Composition of Diets 3111","PeriodicalId":7729,"journal":{"name":"Agricultural and biological chemistry","volume":"30 1","pages":"3111-3112"},"PeriodicalIF":0.0000,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Effects of Dietary Pyrazinamide on the Growth of Weanling Rats Fed with a Nicotinic Acid-free and Tryptophan-limited Diet\",\"authors\":\"K. Shibata\",\"doi\":\"10.1271/BBB1961.55.3111\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pyrazinamide is a strong inhibitor of aminocarboxymuconate semialdehyde decarboxylase (ACMSDase; EC 4.1.1.45) in vivo,1] which activity is thought to be critical in tryptophan-nicotinamide conversion.2 ~ 5) I reported that an intraperitoneal injection of pyrazinamide to rats fed with a nicotinic acid-free and 20% casein diet greatly increased urinary excretion of nicotinamide and its catabolic metabolites such as A^-methylnicotinamide (MNA), ^V 1-methyl-2-pyridone-5-carboxamide (2-Py), and Table I. Composition of Diets 3111\",\"PeriodicalId\":7729,\"journal\":{\"name\":\"Agricultural and biological chemistry\",\"volume\":\"30 1\",\"pages\":\"3111-3112\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Agricultural and biological chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1271/BBB1961.55.3111\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Agricultural and biological chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1271/BBB1961.55.3111","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of Dietary Pyrazinamide on the Growth of Weanling Rats Fed with a Nicotinic Acid-free and Tryptophan-limited Diet
Pyrazinamide is a strong inhibitor of aminocarboxymuconate semialdehyde decarboxylase (ACMSDase; EC 4.1.1.45) in vivo,1] which activity is thought to be critical in tryptophan-nicotinamide conversion.2 ~ 5) I reported that an intraperitoneal injection of pyrazinamide to rats fed with a nicotinic acid-free and 20% casein diet greatly increased urinary excretion of nicotinamide and its catabolic metabolites such as A^-methylnicotinamide (MNA), ^V 1-methyl-2-pyridone-5-carboxamide (2-Py), and Table I. Composition of Diets 3111
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