COVID-19在男性中高流行率和快速进展的原因综述

Neda Taghizabet, Fatemeh Rezaei-Tazangi, Hossein Roghani-Shahraki
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引用次数: 0

摘要

之前的研究已经证明了性别与COVID-19结果之间的关系。此外,这证实了男性比女性更有可能发展为急性疾病,这说明了与COVID-19男性和女性患者相关的杂项数据的重要性。换句话说,激素水平和免疫功能等因素可能会相互作用。了解COVID-19患者性别差异的根本原因,可以为疾病预防和更快治疗创造机会。本研究评估了性别在COVID-19疾病发生和进展中的作用。阐述了性别如何影响新冠肺炎发病机制的基本因素血管紧张素转换酶2 (ACE2),介绍了血小板功能、免疫反应的性别差异以及性激素对免疫功能的影响,并探讨了雄激素对新冠肺炎患者跨膜蛋白丝氨酸蛋白酶2 (TMPRSS2)受体的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review of the reasons for high prevalence and rapid progression of COVID-19 in men
Previous studies have demonstrated a relationship between gender and COVID-19 outcomes. In addition, this is confirmed that men have more danger of progressing an acute type of the illness than women, specifies the significance of miscellaneous data related to male and female patients with COVID-19. In other words, some factors like hormonal levels and immune function may interact with each other. A perception of the fundamental reasons for gender diversities in COVID-19 patients can beget a chance for disease prevention and faster treatment. The present study evaluates the role of gender in the incidence and progression of the COVID-19 disease. It has been explained that how gender affects angiotensin-converting enzyme 2 (ACE2), which is a basic factor for the COVID-19 pathogenesis introducing the sex diversities in platelet function, immune reactions and how sex hormones affect immune functions, also the effect of androgens on transmembrane protein serine protease 2 (TMPRSS2) receptor in COVID-19 patients was investigated.
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