Yu. I. Shvets, Viktoriia Konopelniuk, T. Falalyeyeva
{"title":"实验性肥胖大鼠内源性中毒标志物在奥利司他和胡芦巴生物复合物预防治疗条件下的性别差异","authors":"Yu. I. Shvets, Viktoriia Konopelniuk, T. Falalyeyeva","doi":"10.17721/1728.2748.2023.92.27-32","DOIUrl":null,"url":null,"abstract":"Obesity is a complex disease involving an excessive amount of body fat. Obesity is generally caused by eating too much and physical activity too little. High-calorie diet-induced obesity occurs in both sexes, but more pronounced changes in blood parameters associated with this disease are more common in men. However, the gender-specific mechanisms of obesity development are little known. Therefore, the purpose of our study was to determine the sex-specific response to the content of the middle mass molecules and oligopeptides in the serum of rats under conditions of highcalorie diet consumption and after administration of a bionanocomposite based on fenugreek and orlistat. To do this, we used a modified Gabrielian method and mathematical processing and statistical analysis of the results.","PeriodicalId":33822,"journal":{"name":"Visnik Kiivs''kij nacional''nij universitet imeni Tarasa Sevcenka Istoria","volume":"24 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SEX DIFFERENCES IN THE LEVELS OF MARKERS OF ENDOGENOUS INTOXICATION IN RATS WITH EXPERIMENTAL OBESITY UNDER CONDITION OF PREVENTIVE ADMINISTRATION OF ORLISTAT AND BIONANOCOMPOSITE BASED ON FENUGREEK\",\"authors\":\"Yu. I. Shvets, Viktoriia Konopelniuk, T. Falalyeyeva\",\"doi\":\"10.17721/1728.2748.2023.92.27-32\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Obesity is a complex disease involving an excessive amount of body fat. Obesity is generally caused by eating too much and physical activity too little. High-calorie diet-induced obesity occurs in both sexes, but more pronounced changes in blood parameters associated with this disease are more common in men. However, the gender-specific mechanisms of obesity development are little known. Therefore, the purpose of our study was to determine the sex-specific response to the content of the middle mass molecules and oligopeptides in the serum of rats under conditions of highcalorie diet consumption and after administration of a bionanocomposite based on fenugreek and orlistat. To do this, we used a modified Gabrielian method and mathematical processing and statistical analysis of the results.\",\"PeriodicalId\":33822,\"journal\":{\"name\":\"Visnik Kiivs''kij nacional''nij universitet imeni Tarasa Sevcenka Istoria\",\"volume\":\"24 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Visnik Kiivs''kij nacional''nij universitet imeni Tarasa Sevcenka Istoria\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17721/1728.2748.2023.92.27-32\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Visnik Kiivs''kij nacional''nij universitet imeni Tarasa Sevcenka Istoria","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17721/1728.2748.2023.92.27-32","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SEX DIFFERENCES IN THE LEVELS OF MARKERS OF ENDOGENOUS INTOXICATION IN RATS WITH EXPERIMENTAL OBESITY UNDER CONDITION OF PREVENTIVE ADMINISTRATION OF ORLISTAT AND BIONANOCOMPOSITE BASED ON FENUGREEK
Obesity is a complex disease involving an excessive amount of body fat. Obesity is generally caused by eating too much and physical activity too little. High-calorie diet-induced obesity occurs in both sexes, but more pronounced changes in blood parameters associated with this disease are more common in men. However, the gender-specific mechanisms of obesity development are little known. Therefore, the purpose of our study was to determine the sex-specific response to the content of the middle mass molecules and oligopeptides in the serum of rats under conditions of highcalorie diet consumption and after administration of a bionanocomposite based on fenugreek and orlistat. To do this, we used a modified Gabrielian method and mathematical processing and statistical analysis of the results.