实验性肥胖大鼠内源性中毒标志物在奥利司他和胡芦巴生物复合物预防治疗条件下的性别差异

Yu. I. Shvets, Viktoriia Konopelniuk, T. Falalyeyeva
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引用次数: 0

摘要

肥胖是一种与体内脂肪过多有关的复杂疾病。肥胖通常是由吃得太多和运动太少引起的。高热量饮食引起的肥胖在两性中都有发生,但与这种疾病相关的血液参数变化更明显,在男性中更为常见。然而,肥胖发展的性别特异性机制鲜为人知。因此,我们研究的目的是确定在高热量饮食和给予以胡芦巴和奥利司他为基础的生物复合材料后,大鼠血清中中等质量分子和寡肽含量的性别特异性反应。为此,我们使用了一种改进的加布里埃尔方法,并对结果进行了数学处理和统计分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SEX DIFFERENCES IN THE LEVELS OF MARKERS OF ENDOGENOUS INTOXICATION IN RATS WITH EXPERIMENTAL OBESITY UNDER CONDITION OF PREVENTIVE ADMINISTRATION OF ORLISTAT AND BIONANOCOMPOSITE BASED ON FENUGREEK
Obesity is a complex disease involving an excessive amount of body fat. Obesity is generally caused by eating too much and physical activity too little. High-calorie diet-induced obesity occurs in both sexes, but more pronounced changes in blood parameters associated with this disease are more common in men. However, the gender-specific mechanisms of obesity development are little known. Therefore, the purpose of our study was to determine the sex-specific response to the content of the middle mass molecules and oligopeptides in the serum of rats under conditions of highcalorie diet consumption and after administration of a bionanocomposite based on fenugreek and orlistat. To do this, we used a modified Gabrielian method and mathematical processing and statistical analysis of the results.
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