Stability and Vasoconstrictor Effect of Fluocinonide in Ointment Admixtures

The stability and the vasoconstrictor effect of fluocinonide in admixtures of fluocinonide ointment with other ointments were studied and the following results were obtained. No change in color on the appearance, in apparent pH and in contents of fluocinonide was observed until 4 weeks after the combination. In admixtures of fluocinonide ointment with ointments used emulsion bases, however, the separation of liquid and the decrease of the release of fluocinonide through the cellulose membrane were observed for 1-4 weeks after the combination.when these admixtures were applied on skin of human, furthermore, a tendency of the decrease of the vasoconstrictor effect was showed with the lapse of time. In conclusion, it is desirable to avoid mixing fluocinonide ointment with other ointments used emulsion bases beforehand and giving patients as admixtures.