GtoPdb v.2023.1中的游离脂肪酸受体

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI:10.2218/gtopdb/f24/2023.1

C. Briscoe, A. Brown, Nick Holliday, S. Jenkinson, G. Milligan, A. Monaghan, Leigh A. Stoddart

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摘要

游离脂肪酸受体(FFA，由NC-IUPHAR游离脂肪酸受体小组委员会商定的命名法[116,27])被游离脂肪酸激活。长链饱和和不饱和脂肪酸(包括C14.0(肉豆酸)、C16:0(棕榈酸)、C18:1(油酸)、C18:2(亚油酸)、C18:3、(α-亚麻酸)、C20:4(花生四烯酸)、C20:5、n-3 (EPA)和C22:6、n-3(二十二碳六烯酸))可激活FFA1[9,54,64]和FFA4受体[45,52,94]，而短链脂肪酸(C2(乙酸)、C3(丙酸)、C4(丁酸)和C5(戊酸))可激活FFA2[10,66,90]和FFA3[10,66]受体。已经描述了激动剂结合的FFA1的晶体结构[113]。

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Free fatty acid receptors in GtoPdb v.2023.1

Free fatty acid receptors (FFA, nomenclature as agreed by the NC-IUPHAR Subcommittee on free fatty acid receptors [116, 27]) are activated by free fatty acids. Long-chain saturated and unsaturated fatty acids (including C14.0 (myristic acid), C16:0 (palmitic acid), C18:1 (oleic acid), C18:2 (linoleic acid), C18:3, (α-linolenic acid), C20:4 (arachidonic acid), C20:5,n-3 (EPA) and C22:6,n-3 (docosahexaenoic acid)) activate FFA1 [9, 54, 64] and FFA4 receptors [45, 52, 94], while short chain fatty acids (C2 (acetic acid), C3 (propanoic acid), C4 (butyric acid) and C5 (pentanoic acid)) activate FFA2 [10, 66, 90] and FFA3 [10, 66] receptors. The crystal structure for agonist bound FFA1 has been described [113].

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IUPHAR/BPS Guide to Pharmacology CITE

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