无标签离子通道传感器纳米孔膜芯片的制备与封装

TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference Pub Date : 2007-06-10 DOI:10.1109/SENSOR.2007.4300256

V. Agache, F. Sauter, C. Pudda, R. Blanc, C. Chabrol, P. Caillat, T. Plénat, A. V. Agasøster, L. Ghenim, A. Fuchs

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引用次数: 1

摘要

本文讨论了一种新的无标签离子通道生物传感器结构。该生物芯片由蚀刻在独立的氮化硅(Si3N4)支撑膜上的纳米孔径阵列组成。这些膜应该被脂质双分子层覆盖，脂质双分子层承载生物工程蛋白受体门控离子通道。这种蛋白质复合物用于将特定的结合事件与目标分子转化为电信号。本文重点介绍了该器件的制作和封装。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fabrication and Packaging of Nanoporous Membrane Chips for Label-Free Ion-Channel Transducer Based Biosensor

This paper relates to a new architecture of label-free Ion channel based biosensors. The biochips are composed of nanoaperture arrays etched in a free-standing silicon nitride (Si3N4) supporting membrane. These membranes should be covered lately by a lipid bilayer which hosts bioengineered protein receptors-gated ion channels. This protein complex is used to convert specific binding events with target molecules into an electrical signal. This paper is focusing on the fabrication and packaging of the device.

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TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference

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