Bleomycin: An effective drug for intralesional injection treatment of vascular anomalies

bleomycin was found to have a local sclerosing effect on vascular endothelium with nonspecific inflammatory reaction and occlusion of vessels. 6‒10 It was first therapeutically used bleomycin solution as a sclerosing agent for cystic hygroma by Jura et al with good outcome in 1977. 15 After that, it came more studies and publications worldwide, with similar success, which was initially in Japan, then in Australia, Turkey, Sweden, China, South Africa and other countries. 6‒10,15‒19 In our center, the procedures have been performed by local or sedative anesthesia, if the lesions are small or superficial location. However, for deep lesions of head and neck, particularly those which affect airway, the procedure must be performed under general anesthesia.