A Review of the Prevalence and Diagnostic Points of Cryptosporidium Species in Immunocompromised and Healthy Human Samples in Iran

Cryptosporidium species are important intestinal pathogens with widespread distribution in humans and other hosts. Whereas the parasite causes acute and self-limiting gastroenteritis in people with healthy immune systems, many reports on this infection around the world are limited to people with defective or suppressed immune systems who suffer from a persistent and deadly infection. Using laboratory-serological and molecular methods for the detection of Cryptosporidium species in immunocompromised and healthy human samples, recent studies in Iran indicated that the prevalence of Cryptosporidium species in different samples varied between 0 to 14%. The samples in Iranian studies included human fecal and diarrheic samples from diarrheic children, patients with gastroenteritis, immunocompromised individuals, and people in contact with livestock. Furthermore, some species were reported based on molecular studies including Cryptosporidium parvum and Cryptosporidium hominis. Some studies have also reported Cryptosporidium meleagridis. In this review study, data were collected regarding the prevalence of cryptosporidiosis in high-risk individuals such as children and immunocompromised individuals. The results revealed that the higher prevalence of C. parvum in Iranian studies in the last 10 years may be attributed to the transmission of infection from animal sources.