{"title":"巴克-巴卡草叶提取物的毒理学剖面。在白老鼠的肝脏上(Rattus norvegicus)","authors":"Sitti Ayu, Wahyu Harso, Maghfirahtul Jannah","doi":"10.22487/bioceb.v14i1.15082","DOIUrl":null,"url":null,"abstract":"Hyptis capitata Jacq. plant has been using for traditional medicine. Utilization of medicinal plant must always consider to given dose because of toxic effect when too much medicine is taken. The aim of this study was to measure the liver damage in mouse caused by H. capitata Jacq. leave extract when it was given an excessive dose. Either 300 (P1), 600 (P2) or 900 (P3) µg H. capitata Jacq. leave extract was given orally to mice every 24 hours during 14 days. Zero point five ml ethanol 96% was given daily (K-) and without given anything (K+) was also conducted as a control. The result showed that mice given P3 treatment had the highest liver damage. The liver damage in mice was not statistically significant difference between P3 and K- treatments. The lowest liver damage was in mice given K+ treatment. There was no significant difference between P1 and P2 treatments on mice liver damage. Utilization of medicinal plant as traditional medicine should always be consider to doses.","PeriodicalId":8780,"journal":{"name":"Biocelebes","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Profil Toksikologis Ekstrak Daun Tumbuhan Baka-Baka (Hyptis capitata Jacq.) Pada Hati Tikus Putih (Rattus norvegicus)\",\"authors\":\"Sitti Ayu, Wahyu Harso, Maghfirahtul Jannah\",\"doi\":\"10.22487/bioceb.v14i1.15082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hyptis capitata Jacq. plant has been using for traditional medicine. Utilization of medicinal plant must always consider to given dose because of toxic effect when too much medicine is taken. The aim of this study was to measure the liver damage in mouse caused by H. capitata Jacq. leave extract when it was given an excessive dose. Either 300 (P1), 600 (P2) or 900 (P3) µg H. capitata Jacq. leave extract was given orally to mice every 24 hours during 14 days. Zero point five ml ethanol 96% was given daily (K-) and without given anything (K+) was also conducted as a control. The result showed that mice given P3 treatment had the highest liver damage. The liver damage in mice was not statistically significant difference between P3 and K- treatments. The lowest liver damage was in mice given K+ treatment. There was no significant difference between P1 and P2 treatments on mice liver damage. Utilization of medicinal plant as traditional medicine should always be consider to doses.\",\"PeriodicalId\":8780,\"journal\":{\"name\":\"Biocelebes\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biocelebes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22487/bioceb.v14i1.15082\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocelebes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22487/bioceb.v14i1.15082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
Hyptis capitata Jacq。植物一直被用于传统医药。药用植物的使用必须考虑剂量,因为过量服用会产生毒性作用。本研究的目的是测定大鼠肝损伤程度。当给药过量时留下提取物。300 (P1), 600 (P2)或900 (P3)µg H. capitata Jacq。在14天内,每24小时给小鼠灌胃叶提取物。每天给予0.05 ml 96%的乙醇(K-),不给予任何东西(K+)也作为对照。结果显示,给予P3治疗的小鼠肝损伤最大。P3组与K组对小鼠肝损伤的影响无统计学意义。给予K+治疗的小鼠肝损伤最低。P1和P2处理对小鼠肝损伤无显著性差异。药用植物作为传统药材的利用应始终考虑剂量问题。
Profil Toksikologis Ekstrak Daun Tumbuhan Baka-Baka (Hyptis capitata Jacq.) Pada Hati Tikus Putih (Rattus norvegicus)
Hyptis capitata Jacq. plant has been using for traditional medicine. Utilization of medicinal plant must always consider to given dose because of toxic effect when too much medicine is taken. The aim of this study was to measure the liver damage in mouse caused by H. capitata Jacq. leave extract when it was given an excessive dose. Either 300 (P1), 600 (P2) or 900 (P3) µg H. capitata Jacq. leave extract was given orally to mice every 24 hours during 14 days. Zero point five ml ethanol 96% was given daily (K-) and without given anything (K+) was also conducted as a control. The result showed that mice given P3 treatment had the highest liver damage. The liver damage in mice was not statistically significant difference between P3 and K- treatments. The lowest liver damage was in mice given K+ treatment. There was no significant difference between P1 and P2 treatments on mice liver damage. Utilization of medicinal plant as traditional medicine should always be consider to doses.