R. Gevrenova, D. Zheleva-Dimitrova, S. Ruseva, N. Denkov, S. Konstantinov, V. Lozanov, V. Mitev
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Cytotoxic and Hepatoprotective Effects of Bupleurum flavum Flavonoids on Hepatocellular Carcinoma HEP-G2 Cells
Aims: In this study, we aimed at investigating the possible cytotoxic and hepatoprotective effects of crude extract, flavonoid mixture and pure flavonoids isolated from the aerial parts of Bupleurum flavum Forsk. (Apiaceae) native to Bulgaria. Methods: For the first time flavon C-glycoside vicenin-2 was isolated from B. flavum. Its structure was identified by LC-ESI/MS/MS analysis in positive ion mode. Cytotoxic effects of vicenin-2, as well as the known flavonoid narcissin and B. flavum crude extract at concentrations ranging from Original Research Article
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