{"title":"移植耐受:大局观。我们站在哪里，我们应该去哪里?","authors":"H. Waldmann","doi":"10.1111/cei.12933","DOIUrl":null,"url":null,"abstract":"A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three‐stage tolerance‐inducing strategy for transplanted tissues.","PeriodicalId":10179,"journal":{"name":"Clinical & Experimental Immunology","volume":"49 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Transplantation tolerance: the big picture. Where do we stand, where should we go?\",\"authors\":\"H. Waldmann\",\"doi\":\"10.1111/cei.12933\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three‐stage tolerance‐inducing strategy for transplanted tissues.\",\"PeriodicalId\":10179,\"journal\":{\"name\":\"Clinical & Experimental Immunology\",\"volume\":\"49 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical & Experimental Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/cei.12933\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical & Experimental Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/cei.12933","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Transplantation tolerance: the big picture. Where do we stand, where should we go?
A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three‐stage tolerance‐inducing strategy for transplanted tissues.
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