{"title":"骨髓炎配方中fusidate钠的体外溶出释放度评估","authors":"S. Karuppiah","doi":"10.1109/GTEC.2011.6167701","DOIUrl":null,"url":null,"abstract":"The term osteo- derived from the Greek word osteon, meaning bone, myelo- meaning marrow, and -itis meaning inflammation) simply means an infection of the bone or bone marrow. It can be usefully sub classified on the basis of the causative organism (pyogenic bacteria or mycobacteria), the route, duration and anatomic location of the infection. The aim of the study is to develop the analytical method for the dissolution release of sodium fusidate tablets from it's formulation by HPLC. The dissolution release of this formulation is compared with the Innovator sample Fusidin. The similarity factor (F2) and the difference factor (F1) was evaluated with comparative dissolution profile by comparing the results obtained with our preparation and the marketed innovator preparation. A HPLC method has developed for this formulation and the dissolution profile in 3 different media (pH6.8, 7.0 and pH 7.4) at various time points was estimated.","PeriodicalId":13706,"journal":{"name":"International Conference on Green technology and environmental Conservation (GTEC-2011)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An invitro dissolution release estimation of sodium fusidate from its osteomyelitis formulation\",\"authors\":\"S. Karuppiah\",\"doi\":\"10.1109/GTEC.2011.6167701\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The term osteo- derived from the Greek word osteon, meaning bone, myelo- meaning marrow, and -itis meaning inflammation) simply means an infection of the bone or bone marrow. It can be usefully sub classified on the basis of the causative organism (pyogenic bacteria or mycobacteria), the route, duration and anatomic location of the infection. The aim of the study is to develop the analytical method for the dissolution release of sodium fusidate tablets from it's formulation by HPLC. The dissolution release of this formulation is compared with the Innovator sample Fusidin. The similarity factor (F2) and the difference factor (F1) was evaluated with comparative dissolution profile by comparing the results obtained with our preparation and the marketed innovator preparation. A HPLC method has developed for this formulation and the dissolution profile in 3 different media (pH6.8, 7.0 and pH 7.4) at various time points was estimated.\",\"PeriodicalId\":13706,\"journal\":{\"name\":\"International Conference on Green technology and environmental Conservation (GTEC-2011)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Conference on Green technology and environmental Conservation (GTEC-2011)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/GTEC.2011.6167701\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Conference on Green technology and environmental Conservation (GTEC-2011)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/GTEC.2011.6167701","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
An invitro dissolution release estimation of sodium fusidate from its osteomyelitis formulation
The term osteo- derived from the Greek word osteon, meaning bone, myelo- meaning marrow, and -itis meaning inflammation) simply means an infection of the bone or bone marrow. It can be usefully sub classified on the basis of the causative organism (pyogenic bacteria or mycobacteria), the route, duration and anatomic location of the infection. The aim of the study is to develop the analytical method for the dissolution release of sodium fusidate tablets from it's formulation by HPLC. The dissolution release of this formulation is compared with the Innovator sample Fusidin. The similarity factor (F2) and the difference factor (F1) was evaluated with comparative dissolution profile by comparing the results obtained with our preparation and the marketed innovator preparation. A HPLC method has developed for this formulation and the dissolution profile in 3 different media (pH6.8, 7.0 and pH 7.4) at various time points was estimated.
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