心律失常性心肌病右心室肌细胞肥大的征象

IF 1.6 4区医学 Q3 PRIMARY HEALTH CARE

Primary Health Care Research and Development Pub Date : 2019-01-01 DOI:10.15761/hpc.1000160

S. Peters

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引用次数: 1

摘要

在人和小鼠模型中，粘连蛋白-2的突变产生一种形式的心律失常性心肌病，伴大量坏死和右心室肌细胞肥大。在一组434例典型的心律失常性心肌病患者中，我们在标准心电图中寻找右心室肥厚的迹象。12例(3%)出现明显或轻微的右心室肥厚征象，超出了致心律失常性心肌病的轻微或主要心电图标准。虽然在致心律失常性心肌病中，桥粒蛋白-2突变的频率为5 - 15%，但在致心律失常性心肌病中，右室肥厚的其他征象是大量坏死的提示，从而导致右室肌细胞肥厚。*通信:斯特凡·彼得斯，心脏科，圣伊丽莎白医院，利本哈勒街20号，38259萨尔茨吉特，德国，电话:+39 5341 824 679;电子邮件:H.u.S.Peters@t-online.de

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Signs of right ventricular myocyte hypertrophy in arrhythmogenic cardiomyopathy

In human and mouse models mutations of desmoglein-2 produce a form of arrhythmogenic cardiomyopathy with massive necrosis and right ventricular myocyte hypertrophy. In a cohort of 434 patients with typical arrhythmogenic cardiomyopathy it was searched for signs of right ventricular hypertrophy in standard ECG. In 12 cases manifest or subtle signs of right ventricular hypertrophy were present (3%) beyond minor or major ECG criteria of arrhythmogenic cardiomyopathy. Although desmoglein-2 mutations have a frequency of 5 – 15% in arrhythmogenic cardiomyopathy additional signs of right ventricular hypertrophy are a hint of massive necrosis in arrhythmogenic cardiomyopathy thus producing right ventricular myocyte hypertrophy. *Correspondence to: Stefan Peters, Cardiology, St.Elisabeth Hospital Salzgitter, Liebenhaller Str. 20, 38259 Salzgitter, Germany, Tel: +39 5341 824 679; E-Mail: H.u.S.Peters@t-online.de

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来源期刊

Primary Health Care Research and Development PRIMARY HEALTH CARE-

CiteScore

2.60

自引率

6.20%

发文量

119

审稿时长

33 weeks

期刊介绍： Primary Health Care Research & Development is aimed specifically at both researchers and practitioners in primary health care, bridging the gap between the two areas. It provides a forum for the publication of international, interdisciplinary research and development in primary health care. It is essential reading for all involved in primary care: nurse practitioners, GPs and health service managers; professional and local groups in community health; researchers and academics; purchasers of primary health care services; allied health practitioners in secondary services and health-related consumer groups.