{"title":"竹叶水提物的比较及相互作用研究。维生素C和E对雄性豚鼠基础血清磷酸酶水平的影响","authors":"J. Aprioku, A. Obianime","doi":"10.4314/WAJPDR.V24I1.59051","DOIUrl":null,"url":null,"abstract":"The present study was designed to investigate the comparative effects of aqueous leaf extract of Ocimum gratissimum Linn. (Lamiaceae), vitamin C and vitamin E on the basal serum phosphatases- alkaline phosphatase (ALP), total acid phosphatase (ACPT) and prostatic acid phosphatase (ACPP) of the male guinea-pig. Also investigated were the interactive effects of these agents on the biochemical parameters. Adult male guinea-pigs were divided into nineteen groups of five animals each and orally administered with different doses of O. gratissimum (11-352 mg/kg), vitamin C (1.25-80 mg/kg), vitamin E (75-2400mg/kg) and the last group (control) was given distilled water. Animals were sacrificed after 4h and blood samples collected and analyzed for ALP, ACPT, and ACPP. In another set of animals, O. gratissimum was administered 1h before obtaining the dose-responses of vitamins C and E and vice versa. O. gratissimum (11-352mg/kg), vitamin C (1.25-80mg/kg) and vitamin E (75-2400mg/kg) caused significant (p Keywords: Ocimum gratissimum , basal phosphatase, vitamin C and vitamin E.","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"288 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2010-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Comparative and Interactive Studies of Aqueous Leaf Extracts of Ocimum gratissimum Linn. (Lamiaeceae),Vitamins C and E on the Basal Serum Phosphatase Levels of Male Guinea Pigs\",\"authors\":\"J. Aprioku, A. Obianime\",\"doi\":\"10.4314/WAJPDR.V24I1.59051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study was designed to investigate the comparative effects of aqueous leaf extract of Ocimum gratissimum Linn. (Lamiaceae), vitamin C and vitamin E on the basal serum phosphatases- alkaline phosphatase (ALP), total acid phosphatase (ACPT) and prostatic acid phosphatase (ACPP) of the male guinea-pig. Also investigated were the interactive effects of these agents on the biochemical parameters. Adult male guinea-pigs were divided into nineteen groups of five animals each and orally administered with different doses of O. gratissimum (11-352 mg/kg), vitamin C (1.25-80 mg/kg), vitamin E (75-2400mg/kg) and the last group (control) was given distilled water. Animals were sacrificed after 4h and blood samples collected and analyzed for ALP, ACPT, and ACPP. In another set of animals, O. gratissimum was administered 1h before obtaining the dose-responses of vitamins C and E and vice versa. O. gratissimum (11-352mg/kg), vitamin C (1.25-80mg/kg) and vitamin E (75-2400mg/kg) caused significant (p Keywords: Ocimum gratissimum , basal phosphatase, vitamin C and vitamin E.\",\"PeriodicalId\":23624,\"journal\":{\"name\":\"West African journal of pharmacology and drug research\",\"volume\":\"288 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"West African journal of pharmacology and drug research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/WAJPDR.V24I1.59051\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"West African journal of pharmacology and drug research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/WAJPDR.V24I1.59051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparative and Interactive Studies of Aqueous Leaf Extracts of Ocimum gratissimum Linn. (Lamiaeceae),Vitamins C and E on the Basal Serum Phosphatase Levels of Male Guinea Pigs
The present study was designed to investigate the comparative effects of aqueous leaf extract of Ocimum gratissimum Linn. (Lamiaceae), vitamin C and vitamin E on the basal serum phosphatases- alkaline phosphatase (ALP), total acid phosphatase (ACPT) and prostatic acid phosphatase (ACPP) of the male guinea-pig. Also investigated were the interactive effects of these agents on the biochemical parameters. Adult male guinea-pigs were divided into nineteen groups of five animals each and orally administered with different doses of O. gratissimum (11-352 mg/kg), vitamin C (1.25-80 mg/kg), vitamin E (75-2400mg/kg) and the last group (control) was given distilled water. Animals were sacrificed after 4h and blood samples collected and analyzed for ALP, ACPT, and ACPP. In another set of animals, O. gratissimum was administered 1h before obtaining the dose-responses of vitamins C and E and vice versa. O. gratissimum (11-352mg/kg), vitamin C (1.25-80mg/kg) and vitamin E (75-2400mg/kg) caused significant (p Keywords: Ocimum gratissimum , basal phosphatase, vitamin C and vitamin E.
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