{"title":"新型钒-3-羟基黄酮复合物对链脲佐菌素诱导的实验性糖尿病大鼠的降血脂作用","authors":"Subramanian Iyyam Pillai , Sorimuthu Pillai Subramanian , Muthusamy Kandaswamy","doi":"10.1016/j.bionut.2013.04.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Diabetic dyslipidemia<span>, defined as atherogenic dyslipidemia, is thought to be highly responsible for the increased cardiovascular complications in diabetes mellitus. It is due to hyperglycemia and dysregulation in fatty acid metabolism. Recently, we have reported the antidiabetic and antioxidant properties of a novel vanadium-3-hydroxy flavone complex in streptozotocin-induced diabetic rats. In the present study, diabetic rats were treated with vanadium-3-hydroxy flavone complex (5</span></span> <!-->mg/kg body weight/day) for a period of 30<!--> <span>days and the status of the lipid profile in the serum, liver and kidney was evaluated. The increased levels of lipid contents in serum and tissues observed in diabetic rats were reinstated to near normal levels by the administration of the vanadium-3-hydroxy flavone complex. Also the decreased levels of HDL-cholesterol and increased levels of LDL- and VLDL-cholesterol in serum of diabetic rats were normalized upon treatment with the complex. The results of the present study illustrate the antidyslipidemic property of the vanadium-3-hydroxy flavone complex. The observed antidyslipidemic property of the complex might be due to its insulin mimetic nature.</span></p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 2","pages":"Pages 189-193"},"PeriodicalIF":0.0000,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.04.004","citationCount":"9","resultStr":"{\"title\":\"Antidyslipidemic effect of a novel vanadium-3-hydroxy flavone complex in streptozotocin-induced experimental diabetes in rats\",\"authors\":\"Subramanian Iyyam Pillai , Sorimuthu Pillai Subramanian , Muthusamy Kandaswamy\",\"doi\":\"10.1016/j.bionut.2013.04.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Diabetic dyslipidemia<span>, defined as atherogenic dyslipidemia, is thought to be highly responsible for the increased cardiovascular complications in diabetes mellitus. It is due to hyperglycemia and dysregulation in fatty acid metabolism. Recently, we have reported the antidiabetic and antioxidant properties of a novel vanadium-3-hydroxy flavone complex in streptozotocin-induced diabetic rats. In the present study, diabetic rats were treated with vanadium-3-hydroxy flavone complex (5</span></span> <!-->mg/kg body weight/day) for a period of 30<!--> <span>days and the status of the lipid profile in the serum, liver and kidney was evaluated. The increased levels of lipid contents in serum and tissues observed in diabetic rats were reinstated to near normal levels by the administration of the vanadium-3-hydroxy flavone complex. Also the decreased levels of HDL-cholesterol and increased levels of LDL- and VLDL-cholesterol in serum of diabetic rats were normalized upon treatment with the complex. The results of the present study illustrate the antidyslipidemic property of the vanadium-3-hydroxy flavone complex. The observed antidyslipidemic property of the complex might be due to its insulin mimetic nature.</span></p></div>\",\"PeriodicalId\":100182,\"journal\":{\"name\":\"Biomedicine & Preventive Nutrition\",\"volume\":\"4 2\",\"pages\":\"Pages 189-193\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bionut.2013.04.004\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedicine & Preventive Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210523913000287\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210523913000287","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antidyslipidemic effect of a novel vanadium-3-hydroxy flavone complex in streptozotocin-induced experimental diabetes in rats
Diabetic dyslipidemia, defined as atherogenic dyslipidemia, is thought to be highly responsible for the increased cardiovascular complications in diabetes mellitus. It is due to hyperglycemia and dysregulation in fatty acid metabolism. Recently, we have reported the antidiabetic and antioxidant properties of a novel vanadium-3-hydroxy flavone complex in streptozotocin-induced diabetic rats. In the present study, diabetic rats were treated with vanadium-3-hydroxy flavone complex (5 mg/kg body weight/day) for a period of 30 days and the status of the lipid profile in the serum, liver and kidney was evaluated. The increased levels of lipid contents in serum and tissues observed in diabetic rats were reinstated to near normal levels by the administration of the vanadium-3-hydroxy flavone complex. Also the decreased levels of HDL-cholesterol and increased levels of LDL- and VLDL-cholesterol in serum of diabetic rats were normalized upon treatment with the complex. The results of the present study illustrate the antidyslipidemic property of the vanadium-3-hydroxy flavone complex. The observed antidyslipidemic property of the complex might be due to its insulin mimetic nature.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
