肿瘤干细胞在三阴性乳腺癌中的研究进展

国际肿瘤学杂志 Pub Date : 2019-06-18 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.06.010

Ye Kang, Jianyi Li, Xiang-Hong Yang

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引用次数: 0

摘要

三阴性乳腺癌(TNBC)中存在丰富的肿瘤干细胞(CSCs)。CSCs通过独特的分子机制和肿瘤微环境维持其表型，促进TNBC的化疗耐药和复发。阻断这些关键分子或改变肿瘤微环境可减少CSCs，进而抑制肿瘤生长，逆转TNBC化疗耐药。关键词:乳腺肿瘤;肿瘤干细胞;治疗;耐药;三阴性乳腺肿瘤

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Research progress of cancer stem cells in triple-negative breast cancer

There are abundant cancer stem cells (CSCs) in triple-negative breast cancer (TNBC). CSCs can maintain their phenotype by unique molecular mechanism and tumor microenvironment, and can promote the chemotherapy resistance and recurrence of TNBC. Blocking these key molecules or altering tumor microenvironment can reduce CSCs, and then inhibited cancer growth and reverse chemotherapy resistance of TNBC. Key words: Breast neoplasms; Neoplastic stem cells; Therapy; Drug resistance; Triple negative breast neoplasms

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国际肿瘤学杂志

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12123

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