玻尔兹曼因子,DNA融化,和布朗棘轮:主题在入门物理序列生物学和医学预科学生

S. Mochrie
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引用次数: 7

摘要

提出了三种相互关联的生物学相关的有偏差随机漫步的例子:(1)DNA融化模型,建模为DNA解压缩,这提供了一种说明玻尔兹曼因素在生物学和医学预科学生所熟知的场所中的作用的方法;(2)解旋酶马达蛋白在解压缩双链DNA中的活性,例如,在复制叉处,这是布朗棘轮的一个例子;(3)肌动蛋白聚合产生的力,这是另一种布朗棘轮,肌动蛋白聚合速度的力和肌动蛋白浓度依赖于此棘轮。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Boltzmann factor, DNA melting, and Brownian ratchets: Topics in an introductory physics sequence for biology and premedical students
Three, interrelated biologically-relevant examples of biased random walks are presented: (1) A model for DNA melting, modelled as DNA unzipping, which provides a way to illustrate the role of the Boltzmann factor in a venue well-known to biology and pre-medical students; (2) the activity of helicase motor proteins in unzipping double-stranded DNA, for example, at the replication fork, which is an example of a Brownian ratchet; (3) force generation by actin polymerization, which is another Brownian ratchet, and for which the force and actin-concentration dependence of the velocity of actin polymerization is determined.
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