离子通道中电荷流动的多物理场建模与有限元逼近

Bice Chini, Joseph W. Jerome, Riccardo Sacco
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引用次数: 0

摘要

本通讯涉及单细胞离子通道中电荷传输的数学建模和数值模拟。所采用的模型是一个由泊松-能斯特-普朗克方程和纳维-斯托克斯方程组成的耦合系统。采用合适的泛函迭代技术逐次求解模型方程,采用稳定和保守的有限元方法对解耦引起的各线性化问题进行离散化。通过几种工况下二维离子通道的数值模拟,验证了模型和计算方法的正确性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multi-Physics Modeling and Finite Element Approximation of Charge Flow in Ionic Channels
This communication deals with the mathematical modeling and numerical simulation of charge transport in single-cell ionic channels. The adopted model consists of a coupled system comprising the Poisson-Nernst-Planck and the Navier-Stokes equations. Suitable functional iteration techniques are used to successively solve the model equations, and stable and conservative finite element methods are employed for the discretization of each linearized problem arising from decoupling. Models and computational techniques are validated on the numerical simulation of a two-dimensional ionic channel under several working conditions
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