A Micromachined Multimodal Probe Technology for Ischemia Muscle Monitoring

In this paper, we present a micromachined multimodal probe technology for ischemia muscle monitoring. It is a platform technology to fabricate silicon sensing probes with the characteristics of low-cost, multifunction, and small form factor, which can detect temperature, pH value, and the concentration of K+, NH4+, etc. inside muscle tissue suitable for peripheral arterial occlusive disease detection and intraoperative heart muscle monitoring, respectively. From animal experiments, the micromachined probe has shown its potential to provide physicians a multi-mode diagnosis with corresponding real-time medical treatment feedback.