增加拼图的碎片:从综合研究教育项目中对噬菌体多样性的新见解

W. Pope, G. Hatfull
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引用次数: 12

摘要

噬菌体是生物宇宙中的暗物质:数量庞大,充满了功能未知的新基因。从目前测序的大约2000个噬菌体基因组中收集到的基因组见解,如马赛克结构,远远不能代表生物圈中噬菌体颗粒的总数-约10 × 31。最近对耻垢分枝杆菌mc2155上分离的627个分枝噬菌体的比较分析是迄今为止对这个问题进行的最广泛的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adding pieces to the puzzle: New insights into bacteriophage diversity from integrated research-education programs
Bacteriophages are the dark matter of the biological universe: the population is vast and replete with novel genes whose function is unknown. The genomic insights such as the mosaic architecture gleaned from perhaps 2,000 currently sequenced bacteriophage genomes is far from representative of the total number phage particles in the biosphere - about 10ˆ31. The recent comparative analysis of 627 mycobacteriophages isolated on Mycobacterium smegmatis mc2 155 is the most extensive examination yet in pursuit of this question.
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