海拉细胞系上虎耳草根中细胞毒性咔唑生物碱的研究

Proceedings of the 1st International Conference on Chemical Science and Technology Innovation Pub Date : 2019-01-01 DOI:10.5220/0008858101410144

T. M. Thant, N. Aminah, A. Kristanti, R. Ramadhan, H. Aung, Y. Takaya

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引用次数: 2

摘要

从缅甸药用植物中寻找生物活性成分，从Clausena excavata根中分离到一种咔唑类生物碱，命名为7hydroxy heptaphylline(1)。通过紫外可见光谱、红外光谱、核磁共振和HRMS等光谱数据对化合物的结构进行了分析。分离的化合物(1)通过MTT试验对HeLa癌细胞的细胞毒性进行了评价。化合物(1)具有中等抑制活性，IC50为41.4 μg/ml。

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Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell Line

In a search for bioactive constituents from Myanmar medicinal plants, a carbazole alkaloid, named 7hydroxy heptaphylline (1) was isolated from the root of Clausena excavata. The structure of isolated compound was elucidated based on spectrophotometric data such as UV-vis, FT-IR, NMR and HRMS data. The cytotoxicity of the isolated compound (1) was evaluated by MTT assay against on HeLa cancer cells. The compound (1) exhibited moderate inhibition activity with IC50 41.4 μg/ml.

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Proceedings of the 1st International Conference on Chemical Science and Technology Innovation

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