制药工业中嗜麦芽窄养单胞菌生物膜对消毒剂耐受性的评价

Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI:10.35259/isi.2022_52295

Rebeca Miranda, G. Monteiro, Luiza Vasconcellos, Samara Silva, L. Costa

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引用次数: 0

摘要

对酒精70%(0/36)不能减少形成的生物膜(p = 1.00)。季铵(2/36,5.5%)(p≤0.0023)、次氯酸钠(0.1%，0.5%)对生物膜的还原率分别为38.8%和94.4% (p≤1.32 × 10 -6)。当浓度≥1.0%时，次氯酸钠消除了100%的生物膜。结论:次氯酸钠浓度≥1.0% /15 min是消除嗜麦芽葡萄球菌生物膜最有效的消毒剂。由于次氯酸钠的腐蚀作用，不能用于某些表面，因此有必要进行其他研究，以找到替代消毒剂。

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Evaluation of stenotrophomonas maltophilia biofilm tolerance to disinfectants used in a pharmaceutical industry

to alcohol 70% (0/36) was not able to reduce the biofilm formed ( p = 1.00). Quaternary ammonium (2/36, 5.5%) ( p ≤ 0.0023), sodium hypochlorite at 0.1% and 0.5% were able to reduce the biofilm in 38.8% and 94.4% ( p ≤ 1.32x10 -6 ), respectively. In concentrations ≥ 1.0%, sodium hypochloride eliminated 100% of biofilms. Conclusion: In conclusion, sodium hypochlorite at concentrations ≥ 1.0 %/15 min seems to be the most effective disinfectant for S. maltophilia biofilm elimination. As sodium hypochlorite cannot be applied in certain surfaces due to its corrosive action, other studies are necessary in order to find alternative disinfectants.

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Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes

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