Meng Deng, Haitao Guo, Jason W. Tam, Brandon M. Johnson, W. Brickey, James S. New, Austin R. Lenox, Hexin Shi, D. Golenbock, Beverly H. Koller, Karen P McKinnon, B. Beutler, Jenny P.-Y. Ting
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Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR
Platelet-activating factor (PAF) can drive pathophysiological inflammation, but the mechanism remains incompletely understood. Here, Deng et al. report that PAF activates the canonical NLRP3 inflammasome independently of its receptor PAFR.
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