A Review on in situ Gel of Gastro Retentive Drug Delivery System

The ‘in situ gel’ system has appeared as one of the most effective drug delivery systems. Its specific distinguishing feature of 'Sol to Gel' transition aids in the continuous and controlled release of medicines. These systems have a number of advantages, including simple production, convenience of use, enhanced adherence, and patient comfort by lowering drug delivery frequency due to their distinctive sol to gel transition characteristics. An in-situ gelling system is a formulation that is in solution form before penetrating the body but transforms to gel form under specified physiological conditions. This review mainly focused on introduction, Advantages and Disadvantages of in situ gel, mechanism, types of Polymers used, Evaluation of in situ gel and its applications.