使用电磁胶囊跟踪系统对结肠运动的动态评估:阿片类药物的作用

Neurogastroenterology & Motility Pub Date : 2019-11-12 DOI:10.1111/nmo.13753

E. Mark, M. Klinge, D. Grønlund, J. Poulsen, V. Schlageter, S. Scott, K. Krogh, A. Drewes

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引用次数: 11

摘要

阿片类药物治疗通常会导致虚弱的便秘。然而，阿片类药物是如何影响结肠运动的，以及阿片类药物引起的便秘是由于强大的蠕动收缩减少还是“不协调”的蠕动引起的，目前还没有很好的描述。本研究旨在探讨羟考酮对结肠运动参数的影响，并确定阿片拮抗剂纳洛西戈是否使结肠运动正常化。

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Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system: Effect of opioids

Opioid treatment often causes debilitating constipation. However, it is not well described how opioids affect colonic motility and whether opioid‐induced constipation is due to either a decrease of powerful peristaltic contractions or “uncoordinated” peristalsis. The present study aims to investigate the effect of oxycodone on parameters of colonic motility and to determine whether motility is normalized by the opioid antagonist naloxegol.

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Neurogastroenterology & Motility

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