国药BIBP疫苗接种癌症患者新冠肺炎突破性感染

IF 0.4 Q4 ONCOLOGY
Amirreza Manteghinejad, S. Arabzadeh, Zahra Rezaian, M. Sharifi, S. Haghjooy Javanmard
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引用次数: 0

摘要

背景:癌症患者因COVID-19感染而死亡的风险增加。因此,它们是优先接种疫苗的对象。然而,关于灭活疫苗在预防COVID-19感染、住院和癌症患者死亡率方面的免疫原性、安全性和有效性的数据有限。目的:本研究旨在报道充分接种国药BIBP疫苗后PCR检测阳性患者的临床特征。方法:在这项回顾性研究中,从伊朗伊斯法罕一家癌症中心的电子健康记录中提取癌症患者的数据。伊斯法罕省的所有COVID-19数据也由伊斯法罕COVID-19登记处(I-CORE)收集。我们描述了在第二次给药后14天以上检测结果呈阳性的癌症患者的临床特征。结果:222例癌症患者在开始接种COVID-19疫苗后至少有一次PCR检测阳性。其中发生了9例(4.1%)突破性感染。其中6例(67%)有血液系统恶性肿瘤。6例(67%)住院,3例(33%)死亡。其中两人最近接受了化疗,并患有血液系统恶性肿瘤。结论:疫苗接种是保护人群免受COVID-19并发症和死亡率的好方法,但应考虑到完全接种疫苗的癌症患者存在严重后果的风险。但是,应该优先考虑癌症患者,特别是血液系统恶性肿瘤患者,或接受化疗的患者接种加强疫苗,并研究每种COVID-19疫苗对癌症患者的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 Breakthrough Infections among Patients with Cancer Receiving Sinopharm BIBP Vaccine
Background: Patients with cancer are at an increased risk of mortality from COVID-19 infection. So, they are prioritized for vaccination. However, there is limited data about the immunogenicity, safety, and effectiveness of inactivated vaccines in preventing COVID-19 infection, hospitalization, and mortality in patients with cancer. Objectives: This study aimed to report the clinical characteristics of patients who had a positive PCR test after being fully vaccinated with the Sinopharm BIBP Vaccine. Methods: In this retrospective study, the data of patients with cancer were extracted from the electronic health records of a cancer center in Isfahan, Iran. All COVID-19 data from Isfahan province also was collected by Isfahan COVID-19 Registry (I-CORE). We described the clinical characteristics of patients with cancer who have a positive test more than14 days after the second dose. Results: Two hundred twenty-two patients with cancer had at least one positive PCR test after the start of the COVID-19 vaccination. Of these, 9 (4.1%) breakthrough infections have occurred. Six (67%) of them had hematological malignancies. Six (67%) were hospitalized and 3 (33%) patients died. Two of them had recent chemotherapy and have hematological malignancies. Conclusions: Vaccination is a good way to protect the population from COVID-19 complications and mortality, but it should be considered that fully-vaccinated patients with cancer are at risk of severe outcomes. Nevertheless, prioritizing cancer patients, especially those with hematological malignancies, or receiving chemotherapies for booster vaccines and studying the effectiveness of each COVID-19 vaccine for patients with cancer should be considered.
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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