A comparative study of platelet rich fibrin and bone graft in intrabony defect treatment: A systematic review

Objective: To compare the result of treatment using platelet rich fibrin and bone graft in intrabony defect cases. Methods: Pubmed and Wiley online searches were conducted to identify articles published in dental journals from January 2013 to December 2017 focusing on platelet rich fibrin and bone graft in intrabony defect treatment. Manual searches of published full-text articles and related reviews were performed afterwards. There are 135 studies found, but only 4 studies met the inclusion criteria. Results: The initial database search produced 135 articles. All articles were selected for full-text review. A total 4 studies were selected for inclusion, with 107 patients as subjects. All of the studies showed the decreased of probing depth (PD), clinical attachment loss (CAL), intrabony defect (IBD) or radiograph defect depth (RDD) after 9 months follow up. The differences between baseline and clinical outcome measurement showed that single treatment using bone graft