低纤维异常血症无症状患者凝血酶时间的延长

Q3 Medicine
S. Katakkar
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引用次数: 0

摘要

一名61岁的女性患者,已知诊断为乳腺癌,缓解超过10年,患有雷诺氏病。在她对狼疮和狼疮抗凝血剂的检查中,都是阴性的,凝血酶时间延长了,这是错误的。患者无出血或血栓形成史,最近一次手术是5年前因椎管狭窄,无并发症。临床检查正常,无自发性瘀伤,但手较冷。凝血酶时间在两个不同的场合大于125秒,通过添加正常血浆来校正凝血酶时间降至56秒,因此是不完整的。凝血酶原时间和PTT正常,无FDP或d -二聚体。没有肝素循环的迹象。纤维蛋白原水平正常。正常血清蛋白电泳及免疫固定均可排除para蛋白血症。因此,我们认为该患者有异常纤维蛋白原血症或低异常纤维蛋白原血症,但无出血或血栓并发症。文献综述显示,大约55%的纤维蛋白异常血症患者没有出血或血栓并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prolonged Thrombin Time in Asymptomatic Patient with Hypo Dysfibrogememia Tucson
A 61 years female patient with known diagnosis of the breast cancer in remission for more than 10 years has Renaud’s disease. During her work up for lupus and lupus anticoagulant which both were negative a prolonged thrombin time was noted which was done by mistake. She has no history of bleeding or thrombosis and last recent surgery was 5 years ago for spinal stenosis and was uncomplicated. Her clinical examination is normal without evidence of any spontaneous bruises but colder hands. The thrombin time was greater than 125 seconds on two different occasions and correction of it by addition of normal plasma was down to 56 seconds and was thus incomplete. Her prothrombin time and PTT were normal and there was no evidence of FDP or D-Dimers. There was no evidence of circulating heparins. The fibrinogen level was normal. The para proteinmia was excluded by normal serum protein electrophoresis and by immunofixation . Thus it is felt that this patient has dysfibrinogenemia or hypo dysfibrinogenemia without bleeding or thrombotic complication. The literature review shows approximately 55% of dysfibrinogenemia patients do not have bleeding or thrombotic complications.
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
32
审稿时长
12 weeks
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