硫酸盐-β-环糊精模板化的异色染料碱性橙21的聚集:光物理研究

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Supramolecular Chemistry Pub Date : 2021-08-03 DOI:10.1080/10610278.2022.2046277

G. Singh, V. R. Singh, Shrishti P. Pandey, Prabhat K. Singh

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引用次数: 3

摘要

最近发现的分子转子和超生命染料，碱性橙-21 (BO21)，显示出通过异色(颜色改变)改善白细胞的差异计数，这被认为是由于发色团的聚集。因此，对BO21的聚集行为的研究具有特殊的重要性，可以帮助我们描述它的光谱行为。在这篇论文中，我们利用基态吸收、稳态和时间分辨发射光谱(包括超快荧光光谱)和分子对接计算，研究了BO21在带负电荷的超分子宿主硫酸盐-β-环糊精(SC)存在下的光物理行为。BO21的光谱特征在SCD的存在下显示出极端的调制，其特征与BO21在其偏色差行为期间观察到的特征相似。根据SCD附近BO21分子的聚集，这些光谱特征已经得到了合理的解释，这些BO21分子对外界刺激也非常敏感，比如离子强度和介质温度。图形抽象

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Sulfated-β-cyclodextrin templated aggregation of a metachromatic dye, Basic Orange 21: A photophysical investigation

ABSTRACT The recently discovered molecular rotor and supravital dye, Basic Orange-21 (BO21), has shown improved differential counting of leukocytes through metachromasia (change in colour), which is believed to be due to the aggregation of chromophores. Thus, investigation on the aggregation behaviour of BO21 holds special importance and may help us to delineate its spectroscopic behaviour. In this contribution, we have investigated the photophysical behaviour of BO21 in presence of a negatively charged supramolecular host, sulfated-β-cyclodextrin (SC), using ground-state absorption, steady-state and time-resolved emission spectroscopy including ultrafast fluorescence spectroscopy, and molecular docking calculations. The spectral characteristics of BO21 display extreme modulations in presence of SCD, with features similar to that observed for BO21 during its metachromatic behaviour. These spectroscopic features have been rationalised in terms of aggregation of BO21 molecules in the vicinity of SCD, which are also extremely sensitive to external stimuli, such as, ionic strength and temperature of the medium. Graphical abstract

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

期刊介绍： Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. . The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.