新型吡唑-4-羧酸酰胺衍生物的抗菌和抗结核活性:合成和表征

Q2 Pharmacology, Toxicology and Pharmaceutics

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI:10.7324/japs.2023.119430

C. Deepthi, J. Prathyusha

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引用次数: 0

摘要

目前的研究旨在鉴定最新一类抗真菌、抗菌和抗结核的先导化合物。通过使用羧基酰胺连接，最近的研究设计并合成了一类独特的吡唑基芳基胺分子杂合体。采用多步法，制备了所需的吡唑羧酰胺衍生物。用1hnmr、c13nmr和质谱技术对化合物进行了表征。对这些物质进行了抗菌、抗真菌和抗结核的测试。所有化合物对革兰氏阳性和革兰氏阴性病原菌和真菌均表现出良好的抑菌活性。化合物5i对革兰氏阳性病原菌具有强效活性，化合物5k对革兰氏阴性病原菌具有强效活性，化合物5a、5i和5j对真菌菌株和结核分枝杆菌H37Rv菌株具有强效活性。

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Antimicrobial and antitubercular activity of novel pyrazole-4-carboxamide derivatives: Synthesis and characterization

The current research aims to identify the newest class of antifungal, antibacterial, and antitubercular lead compounds. Through the use of a carboxamide linkage, recent research has designed and synthesized a unique class of pyrazole-based molecular hybrids of aryl amines. Using a multistep method, the desired pyrazole carboxamide derivative was prepared. Compounds were characterized using 1 HNMR, C 13 NMR, and MASS spectral techniques. These substances were tested for their ability as antibacterial, antifungal, and antitubercular agents. All the compounds tested against Gram-positive and Gram-negative pathogens and fungal strains showed good antibacterial activity. Against Gram-positive pathogens, compound 5i showed potent activity, compound 5k demonstrated potent activity against Gram-negative strains, and compounds 5a, 5i, and 5j established potent activity against fungal strains and the Mycobacterium tuberculosis H37Rv strain.

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来源期刊

journal of applied pharmaceutical science Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

2.20

自引率

0.00%

发文量

224

期刊介绍： Journal of Applied Pharmaceutical Science (JAPS) is a monthly, international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. JAPS publishes manuscripts (Original research and review articles Mini-reviews, Short communication) on original work, either experimental or theoretical in the following areas; Pharmaceutics & Biopharmaceutics Novel & Targeted Drug Delivery Nanotechnology & Nanomedicine Pharmaceutical Chemistry Pharmacognosy & Ethnobotany Phytochemistry Pharmacology & Toxicology Pharmaceutical Biotechnology & Microbiology Pharmacy practice & Hospital Pharmacy Pharmacogenomics Pharmacovigilance Natural Product Research Drug Regulatory Affairs Case Study & Full clinical trials Biomaterials & Bioactive polymers Analytical Chemistry Physical Pharmacy.