干细胞与心血管组织修复:机制、方法和临床应用

Qi Zhang , Rosalina Madonna , Weifeng Shen , Emerson Perin , Franca S. Angeli , Ferid Murad , Edward Yeh , L. Maximilian Buja , Raffaele De Caterina , James T. Willerson , Yong-Jian Geng
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引用次数: 13

摘要

心脏干细胞疗法正在成为治疗心脏病患者的一种潜在的新疗法。实验研究和临床试验表明,干细胞移植可以在增强心肌灌注、修复或再生方面取得一定程度的成功,从而改善心脏功能。不同类型的干细胞,包括来自胚胎和成年组织的干细胞已经被测试,并且每种干细胞类型都有优点和缺点。最适合心脏细胞治疗的干细胞类型很难确定,但这类细胞的特征通常是其高存活、生长和分化潜力以及融入宿主组织的潜力。根据病变大小和位置选择合适的递送方法也是干细胞治疗成功的关键因素。来自心脏干细胞治疗的实验性干细胞研究和临床试验的初步数据存在争议,但令人鼓舞。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stem cells and cardiovascular tissue repair: Mechanism, methods, and clinical applications

Cardiac stem cell therapy is emerging as a potential novel treatment for patients with heart disease. Experimental studies and clinical trials have shown that stem cell transplantation can achieve certain degrees of success in enhancing myocardial perfusion, repair or regeneration, leading to improvement of cardiac function. Different types of stem cells including those from embryonic and adult tissues have been tested, and each stem cell type has advantages and disadvantages. The stem cell type(s) most suitable for cardiac cell therapy is hard to define, but such cells are usually characterized by their high potential for survival, growth, and differentiation as well as integration into the host tissue. Selection of proper delivery methods according to lesion size and location is also a critical factor for the success of stem cell therapy. Preliminary data from experimental stem cell research and clinical trials for cardiac stem cell therapy are controversial, yet encouraging.

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