V. Cornejo-Dávila , G.S. García-de la Torre , M.A. Palmeros-Rodríguez , I. Uberetagoyena-Tello de Meneses , J.E. Sedano-Basilio , L. Trujillo-Ortiz , J. Gómez-Sánchez , J.A. Herrera-Muñoz , D.A. Preciado-Estrella , N. Olavarría-Sayavedra , M. Cantellano-Orozco , G. Fernández-Noyola , C. Martínez-Arroyo , J.G. Morales-Montor , C. Pacheco-Gahbler
{"title":"前列腺癌和骨转移患者对雄激素剥夺治疗反应的相关因素","authors":"V. Cornejo-Dávila , G.S. García-de la Torre , M.A. Palmeros-Rodríguez , I. Uberetagoyena-Tello de Meneses , J.E. Sedano-Basilio , L. Trujillo-Ortiz , J. Gómez-Sánchez , J.A. Herrera-Muñoz , D.A. Preciado-Estrella , N. Olavarría-Sayavedra , M. Cantellano-Orozco , G. Fernández-Noyola , C. Martínez-Arroyo , J.G. Morales-Montor , C. Pacheco-Gahbler","doi":"10.1016/j.uromx.2016.05.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Metastatic prostate cancer is a frequent disease in Mexico. There are factors that can be associated with an adequate response to androgen deprivation therapy. Other therapeutic regimens have been proposed to improve results.</p></div><div><h3>Aim</h3><p>To identify factors influencing the response to androgen deprivation therapy in patients with prostate cancer and bone metastases.</p></div><div><h3>Materials and methods</h3><p>The study covered a 7-year period and included patients that presented with metastatic prostate cancer. Patient factors were evaluated during androgen deprivation therapy and follow-up. The association between factors and response was assessed through bivariate and multivariate analyses.</p></div><div><h3>Results</h3><p>Eighty-nine patients were included in the study. The factors associated with the development of castration resistance were: age, Gleason score, prostate-specific antigen reduction<!--> <!-->><!--> <!-->95%, less than 9 months to reach the nadir, and androgen deprivation therapy duration. Having received palliative radiotherapy and periods of intermittence were the factors that were contrastingly associated with cancer-specific mortality. Other factors related to prostate-specific antigen kinetics were not statistically significant in the multivariate analysis.</p></div><div><h3>Conclusions</h3><p>The described factors were associated with the response to androgen deprivation therapy in patients with metastatic prostate cancer.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2016.05.005","citationCount":"0","resultStr":"{\"title\":\"Factores asociados con la respuesta a la terapia de privación androgénica en pacientes con cáncer de próstata y metástasis óseas en una institución\",\"authors\":\"V. Cornejo-Dávila , G.S. García-de la Torre , M.A. Palmeros-Rodríguez , I. Uberetagoyena-Tello de Meneses , J.E. Sedano-Basilio , L. Trujillo-Ortiz , J. Gómez-Sánchez , J.A. Herrera-Muñoz , D.A. Preciado-Estrella , N. Olavarría-Sayavedra , M. Cantellano-Orozco , G. Fernández-Noyola , C. Martínez-Arroyo , J.G. Morales-Montor , C. Pacheco-Gahbler\",\"doi\":\"10.1016/j.uromx.2016.05.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Metastatic prostate cancer is a frequent disease in Mexico. There are factors that can be associated with an adequate response to androgen deprivation therapy. Other therapeutic regimens have been proposed to improve results.</p></div><div><h3>Aim</h3><p>To identify factors influencing the response to androgen deprivation therapy in patients with prostate cancer and bone metastases.</p></div><div><h3>Materials and methods</h3><p>The study covered a 7-year period and included patients that presented with metastatic prostate cancer. Patient factors were evaluated during androgen deprivation therapy and follow-up. The association between factors and response was assessed through bivariate and multivariate analyses.</p></div><div><h3>Results</h3><p>Eighty-nine patients were included in the study. The factors associated with the development of castration resistance were: age, Gleason score, prostate-specific antigen reduction<!--> <!-->><!--> <!-->95%, less than 9 months to reach the nadir, and androgen deprivation therapy duration. Having received palliative radiotherapy and periods of intermittence were the factors that were contrastingly associated with cancer-specific mortality. 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Factores asociados con la respuesta a la terapia de privación androgénica en pacientes con cáncer de próstata y metástasis óseas en una institución
Background
Metastatic prostate cancer is a frequent disease in Mexico. There are factors that can be associated with an adequate response to androgen deprivation therapy. Other therapeutic regimens have been proposed to improve results.
Aim
To identify factors influencing the response to androgen deprivation therapy in patients with prostate cancer and bone metastases.
Materials and methods
The study covered a 7-year period and included patients that presented with metastatic prostate cancer. Patient factors were evaluated during androgen deprivation therapy and follow-up. The association between factors and response was assessed through bivariate and multivariate analyses.
Results
Eighty-nine patients were included in the study. The factors associated with the development of castration resistance were: age, Gleason score, prostate-specific antigen reduction > 95%, less than 9 months to reach the nadir, and androgen deprivation therapy duration. Having received palliative radiotherapy and periods of intermittence were the factors that were contrastingly associated with cancer-specific mortality. Other factors related to prostate-specific antigen kinetics were not statistically significant in the multivariate analysis.
Conclusions
The described factors were associated with the response to androgen deprivation therapy in patients with metastatic prostate cancer.
期刊介绍:
Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.