颈动脉体研究的历史和最新进展。

4区 生物学 Q3 Medicine
Nikolai E Lazarov, Dimitrinka Y Atanasova
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引用次数: 0

摘要

本章介绍了颈动脉体(CB)的历史以及随后对其结构和功能的研究。关于它作为神经节的解剖结构的想法的时间发展,关于它作为高度血管组织球(肾小球)的腺性质的第一次描述,其神经嵴起源的发现和作为真正副神经节的相关胚胎学观点,以及对其作为血液化学变化的化学受体的感觉性质的更确切的理解,已经得到了一致的证明。CB神经化学、生理学和病理生理学的知识在过去的一个世纪里取得了巨大的进步,在过去的二十年里,积累了大量令人信服的证据,证明CB中存在神经原性小生境,从而为其功能和细胞替代疗法的发展奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
History and Recent Progress in Carotid Body Studies.

This chapter describes the history of the carotid body (CB) and the subsequent research on its structure and function. The chronological development of ideas about its anatomical structure as a ganglion, the first descriptions of its glandular nature as a ball of highly vascular tissue (glomus), the discovery of its neural crest origin and relevant embryological views as a true paraganglion toward a more conclusive understanding of its sensory nature as a chemoreceptor for chemical changes in blood have been consistently demonstrated. The knowledge of the CB neurochemistry, physiology and pathophysiology has progressed immensely in the past century and a large and compelling body of evidence for the presence of a neurogenic niche in the CB has accumulated over the last two decades, thus underlying its function and possibility for the development of cell replacement therapies.

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来源期刊
CiteScore
2.00
自引率
0.00%
发文量
0
期刊介绍: "Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.
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