SLC26阴离子转运蛋白。

Q1 Pharmacology, Toxicology and Pharmaceutics

Handbook of experimental pharmacology Pub Date : 2024-01-01 DOI:10.1007/164_2023_698

Eric R Geertsma, Dominik Oliver

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引用次数: 0

摘要

溶质载体家族26（SLC26）是一个功能多样的阴离子转运蛋白家族，存在于生命的各个领域。SLC26蛋白质转运的阴离子包括氯化物、碳酸氢盐和硫酸盐，也包括富马酸盐和草酸盐等小型有机二羧酸盐。人类基因组编码十种功能同源物，其中几种与严重的人类疾病有因果关系，突出了它们的生理重要性。在此，我们回顾了对SLC26蛋白结构和功能的新见解，并总结了人类成员的生理相关性。

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SLC26 Anion Transporters.

Solute carrier family 26 (SLC26) is a family of functionally diverse anion transporters found in all kingdoms of life. Anions transported by SLC26 proteins include chloride, bicarbonate, and sulfate, but also small organic dicarboxylates such as fumarate and oxalate. The human genome encodes ten functional homologs, several of which are causally associated with severe human diseases, highlighting their physiological importance. Here, we review novel insights into the structure and function of SLC26 proteins and summarize the physiological relevance of human members.

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来源期刊

Handbook of experimental pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unrivalled reference source.