HU 210:研究大麻酚系统的有效工具

Alessandra Ottani, Daniela Giuliani
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引用次数: 51

摘要

合成化合物HU 210显示出多种生物化学、药理学和行为效应,其中大多数已被证明依赖于CB1和CB2大麻素受体的选择性激动活性,并涉及主要的神经递质系统。在各种研究中获得的结果表明,这种强效药物(例如,作为解热、抗炎、镇痛、止吐和抗精神病药物)具有潜在的临床应用潜力,并且它在旨在更好地了解内源性大麻素系统参与多种生理病理功能的研究中是有用的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HU 210: A Potent Tool for Investigations of the Cannabinoid System

The synthetic compound HU 210 displays a multiplicity of biochemical, pharmacological, and behavioral effects, most of which have been demonstrated to be dependent on a selective agonistic activity at CB1 and CB2 cannabinoid receptors and to involve the main neurotransmitter systems. Results obtained in various studies suggest a potential clinical application of this highly potent drug (e.g., as antipyretic, antiinflammatory, analgesic, antiemetic, and antipsychotic agent) as well as its usefulness in research aimed to develop a better understanding of the involvement of the endogenous cannabinoid system in a number of physiopathological functions.

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