{"title":"烟碱乙酰胆碱受体CHRNA5/A3/B4基因簇与年轻学生尼古丁依赖关系的证据","authors":"Yann Le Strat , Nicolas Ramoz , Philip Gorwood","doi":"10.1016/j.fjpsy.2020.09.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The <em>CHRNA5/A3/B4</em> acetylcholine receptor gene cluster has been strongly and repeatedly associated with tobacco dependence, but the studied populations were usually made of adults, with frequently associated somatic comorbidities (such as lung cancer).</p></div><div><h3>Methods</h3><p>Four SNPs within this gene, previously associated with tobacco dependence, were tested in a large population of untreated, young French students (average age, 20 years old).</p></div><div><h3>Results</h3><p>We found strong evidence (surviving corrections for multiple comparisons) that different genetic variants within the studied cluster of genes (rs637137, rs3813567, and an ‘AGG’ haplotype based on rs637137, rs3813567 and rs16969968) are able to distinguish the presence of tobacco dependence in adolescents.</p></div><div><h3>Conclusions</h3><p>The present results argue in favor of the possibility to use different genetic markers of the <em>CHRNA5/A3/B4</em> acetylcholine receptor gene cluster in adolescents, to potentially help more specifically those that need it most (as carrying risk alleles), interventions leading to more benefits when performed in young subjects, or proposed early in the process of tobacco use disorder.</p></div>","PeriodicalId":12420,"journal":{"name":"French Journal of Psychiatry","volume":"2 ","pages":"Pages 49-53"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Evidence for the association of the nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster and nicotine dependence in a young population of students\",\"authors\":\"Yann Le Strat , Nicolas Ramoz , Philip Gorwood\",\"doi\":\"10.1016/j.fjpsy.2020.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The <em>CHRNA5/A3/B4</em> acetylcholine receptor gene cluster has been strongly and repeatedly associated with tobacco dependence, but the studied populations were usually made of adults, with frequently associated somatic comorbidities (such as lung cancer).</p></div><div><h3>Methods</h3><p>Four SNPs within this gene, previously associated with tobacco dependence, were tested in a large population of untreated, young French students (average age, 20 years old).</p></div><div><h3>Results</h3><p>We found strong evidence (surviving corrections for multiple comparisons) that different genetic variants within the studied cluster of genes (rs637137, rs3813567, and an ‘AGG’ haplotype based on rs637137, rs3813567 and rs16969968) are able to distinguish the presence of tobacco dependence in adolescents.</p></div><div><h3>Conclusions</h3><p>The present results argue in favor of the possibility to use different genetic markers of the <em>CHRNA5/A3/B4</em> acetylcholine receptor gene cluster in adolescents, to potentially help more specifically those that need it most (as carrying risk alleles), interventions leading to more benefits when performed in young subjects, or proposed early in the process of tobacco use disorder.</p></div>\",\"PeriodicalId\":12420,\"journal\":{\"name\":\"French Journal of Psychiatry\",\"volume\":\"2 \",\"pages\":\"Pages 49-53\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"French Journal of Psychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590241520300180\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"French Journal of Psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590241520300180","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evidence for the association of the nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster and nicotine dependence in a young population of students
Background
The CHRNA5/A3/B4 acetylcholine receptor gene cluster has been strongly and repeatedly associated with tobacco dependence, but the studied populations were usually made of adults, with frequently associated somatic comorbidities (such as lung cancer).
Methods
Four SNPs within this gene, previously associated with tobacco dependence, were tested in a large population of untreated, young French students (average age, 20 years old).
Results
We found strong evidence (surviving corrections for multiple comparisons) that different genetic variants within the studied cluster of genes (rs637137, rs3813567, and an ‘AGG’ haplotype based on rs637137, rs3813567 and rs16969968) are able to distinguish the presence of tobacco dependence in adolescents.
Conclusions
The present results argue in favor of the possibility to use different genetic markers of the CHRNA5/A3/B4 acetylcholine receptor gene cluster in adolescents, to potentially help more specifically those that need it most (as carrying risk alleles), interventions leading to more benefits when performed in young subjects, or proposed early in the process of tobacco use disorder.
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