复方新诺明预防机会性感染对感染艾滋病毒的儿童是安全有效的

Evidence-based Healthcare and Public Health Pub Date : 2005-06-01 DOI:10.1016/j.ehbc.2005.03.005

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引用次数: 0

摘要

问题复方三唑预防机会性感染是否能降低1岁以上HIV感染儿童的死亡率和住院率？研究设计双盲随机对照试验。主要结果在1岁以上感染艾滋病毒的儿童中，与安慰剂相比，复方三恶唑预防机会性感染在近19个月时减少了死亡和住院人数。两组中与治疗相关的不良事件数量相似（见结果表）。作者的结论：尽管局部细菌对该药物有耐药性，但感染艾滋病毒的儿童应在资源匮乏的环境中接受复方新诺明预防治疗。

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Co-trimoxazole prophylaxis against opportunistic infections is safe, and effective in HIV-infected children

Question

Does co-trimoxazole prophylaxis against opportunistic infections reduce mortality and hospital admissions in HIV-infected children more than 1 year old?

Study design

Double blind randomised controlled trial.

Main results

In HIV-infected children more than 1 year old, co-trimoxazole prophylaxis against opportunistic infections reduced deaths and hospital admissions compared with placebo at nearly 19 months. The number of treatment related adverse events were similar in both groups (see results table).

Authors’ conclusions

Children with HIV infection should receive cotrimoxazole prophylaxis in resource-poor settings, despite local bacterial resistance to this drug.

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来源期刊

Evidence-based Healthcare and Public Health

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