E. Jenabi , S. Bashirian , F. Fariba , B. Naghshtabrizi
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引用次数: 8
摘要
背景与目的据我们所知,这是首次基于观察性研究,对先天性心脏病(CHD)与注意力缺陷/多动障碍(ADHD)或自闭症谱系障碍(ASD)风险之间的关系进行荟萃分析。方法从最早的一年到2020年12月,系统地检索PubMed、Web of Science和Scopus。使用卡方检验进行异质性,并使用I2统计量测量其数量。发表偏倚采用Egger和Begg线性回归检验进行评估。结果是使用比值比(OR)报告的,其95%置信区间(CI)使用随机效应模型估计。结果截至2020年12月,共有812篇引文被纳入搜索初始,其中467164名儿童。根据随机效应模型,ASD与CHD相关风险的估计OR为OR=1.35(95%CI:1.17,1.52;6项研究;I2=0.0%),ADHD与CHD的风险为OR=3.04(95%CI:1.58,4.49;15项研究;I2=88.1%)。因此,应考虑对患有冠心病的幼儿进行ASD和ADHD筛查。
The association between congenital heart disease and the risk of Autism spectrum disorders or attention-deficit/hyperactivity disorder among children: a meta-analysis
Background and objective
To our knowledge, this is the first meta-analysis conducted about the association between congenital heart disease (CHD) and the risk of attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorders (ASD) based on observational studies.
Methods
PubMed, Web of Science, and Scopus were systematically searched from the earliest possible year to December 2020. Heterogeneity was conducted using the chi-square test and its quantity was measured using the I2 statistic. The publication bias was assessed using Egger's and Begg's line regression tests. The results were reported using the odds ratio (OR) estimated with its 95% confidence interval (CI) using a random-effects model.
Results
In total, 812 citations were included in the search initial until December 2020 with 467,164 children. Based on the random effect model, the estimated OR of the risk of ASD associated with CHD was OR=1.35 (95% CI: 1.17, 1.52; 6 studies; I2=0.0%) and the risk of ADHD associated with CHD was OR=3.04 (95% CI: 1.58, 4.49; 15 studies; I2=88.1%).
Conclusions
Our findings suggested that CHD is a risk factor for ASD and ADHD. Therefore, Screening for ASD and ADHD should be considered among young children with CHD.
期刊介绍:
The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.