白足鼠(Peromyscus Leucpus)的遗传和表观遗传多样性跨范围扩展模式。

IF 2.2 4区 生物学 Q2 BIOLOGY
Integrative Organismal Biology Pub Date : 2023-10-30 eCollection Date: 2023-01-01 DOI:10.1093/iob/obad038
T L Rubi, J R do Prado, L L Knowles, B Dantzer
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引用次数: 0

摘要

处于范围扩张前沿的人群必须迅速适应新的条件。表观遗传多样性的增加被假设为通过非遗传表型变异促进适应和种群持久性,特别是当种群扩张时遗传多样性减少时(即表观遗传多样化补偿了低遗传多样性)。在这项研究中,我们使用遗传和表观遗传多样性的空间分布,在白足鼠(Peromyscus leucopus)种群中测试这一假设,该种群是在所谓的最近范围扩展梯度中采样的。我们发现,表观遗传学补偿假说得到了混合支持,而对范围边缘小鼠种群扩张的预期缺乏支持,这可能反映了密歇根上半岛白足小鼠扩张的复杂历史。具体而言,与其他扩展种群相比,在所谓的范围扩展边缘的种群中,表观遗传多样性没有增加。然而,来自额外祖先来源种群的输入可能增加了该范围边缘种群的遗传多样性,抵消了扩张的预期遗传后果,并减少了范围边缘表观遗传多样性增加的好处。未来的工作将扩大重点人群,将具有单一创始谱系的扩展区域包括在内,以测试总体趋势的稳健性,该趋势支持在从单一历史来源建立的扩展人群中观察到的表观遗传变异对遗传多样性减少的假设补偿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Patterns of Genetic And Epigenetic Diversity Across A Range Expansion in The White-Footed Mouse (<i>Peromyscus Leucopus</i>).

Patterns of Genetic And Epigenetic Diversity Across A Range Expansion in The White-Footed Mouse (<i>Peromyscus Leucopus</i>).

Patterns of Genetic And Epigenetic Diversity Across A Range Expansion in The White-Footed Mouse (Peromyscus Leucopus).

Populations at the leading front of a range expansion must rapidly adapt to novel conditions. Increased epigenetic diversity has been hypothesized to facilitate adaptation and population persistence via non-genetic phenotypic variation, especially if there is reduced genetic diversity when populations expand (i.e., epigenetic diversity compensates for low genetic diversity). In this study, we use the spatial distribution of genetic and epigenetic diversity to test this hypothesis in populations of the white-footed mouse (Peromyscus leucopus) sampled across a purported recent range expansion gradient. We found mixed support for the epigenetic compensation hypothesis and a lack of support for expectations for expansion populations of mice at the range edge, which likely reflects a complex history of expansion in white-footed mice in the Upper Peninsula of Michigan. Specifically, epigenetic diversity was not increased in the population at the purported edge of the range expansion in comparison to the other expansion populations. However, input from an additional ancestral source populations may have increased genetic diversity at this range edge population, counteracting the expected genetic consequences of expansion, as well as reducing the benefit of increased epigenetic diversity at the range edge. Future work will expand the focal populations to include expansion areas with a single founding lineage to test for the robustness of a general trend that supports the hypothesized compensation of reduced genetic diversity by epigenetic variation observed in the expansion population that was founded from a single historical source.

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来源期刊
CiteScore
3.70
自引率
6.70%
发文量
48
审稿时长
20 weeks
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