Man Li YANG , Jing Ya WANG , Xing Yu ZONG , Li GUAN , Hui Zhen LI , Yi Bai XIONG , Yu Qin LIU , Ting LI , Xin Yu JI , Xi Yu SHANG , Hui Fang ZHANG , Yang GUO , Zhao Yuan GONG , Lei ZHANG , Lin TONG , Ren Bo CHEN , Yi Pin FAN , Jin QIN , Fang WANG , Gang LIN , Yan MA
{"title":"新冠肺炎布鲁氏菌病患者的治疗结果：黑龙江病例系列和文献系统回顾。","authors":"Man Li YANG , Jing Ya WANG , Xing Yu ZONG , Li GUAN , Hui Zhen LI , Yi Bai XIONG , Yu Qin LIU , Ting LI , Xin Yu JI , Xi Yu SHANG , Hui Fang ZHANG , Yang GUO , Zhao Yuan GONG , Lei ZHANG , Lin TONG , Ren Bo CHEN , Yi Pin FAN , Jin QIN , Fang WANG , Gang LIN , Yan MA","doi":"10.3967/bes2023.035","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Clinical characteristics and outcome in COVID-19 with brucellosis patients has not been well demonstrated, we tried to analyze clinical outcome in local and literature COVID-19 cases with brucellosis before and after recovery.</p></div><div><h3>Methods</h3><p>We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15, 2020 to April 29, 2022. Demographics, epidemiological, clinical symptoms, radiological and laboratory data, treatment medicines and outcomes, and follow up were analyzed, and findings of a systematic review were demonstrated.</p></div><div><h3>Results</h3><p>A total of four COVID-19 with brucellosis patients were included. One patient had active brucellosis before covid and 3 patients had nonactive brucellosis before brucellosis. The median age was 54.5 years, and all were males (100.0%). Two cases (50.0%) were moderate, and one was mild and asymptomatic, respectively. Three cases (75.0%) had at least one comorbidity (brucellosis excluded). All 4 patients were found in COVID-19 nucleic acid screening. Case C and D had only headache and fever on admission, respectively. Four cases were treated with Traditional Chinese medicine, western medicines for three cases, no adverse reaction occurred during hospitalization. All patients were cured and discharged. Moreover, one case (25.0%) had still active brucellosis without re-positive COVID-19, and other three cases (75.0%) have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after recovery. Conducting the literature review, two similar cases have been reported in two case reports, and were both recovered, whereas, no data of follow up after recovery.</p></div><div><h3>Conclusion</h3><p>These cases indicate that COVID-19 patients with brucellosis had favorable outcome before and after recovery. More clinical studies should be conducted to confirm our findings.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 930-939"},"PeriodicalIF":3.0000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001484/pdf?md5=179cedc576f6cbb3abaf71bfa5c5b17b&pid=1-s2.0-S0895398823001484-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Treatment Outcomes in COVID-19 Patients with Brucellosis: Case Series in Heilongjiang and Systematic Review of Literature\",\"authors\":\"Man Li YANG , Jing Ya WANG , Xing Yu ZONG , Li GUAN , Hui Zhen LI , Yi Bai XIONG , Yu Qin LIU , Ting LI , Xin Yu JI , Xi Yu SHANG , Hui Fang ZHANG , Yang GUO , Zhao Yuan GONG , Lei ZHANG , Lin TONG , Ren Bo CHEN , Yi Pin FAN , Jin QIN , Fang WANG , Gang LIN , Yan MA\",\"doi\":\"10.3967/bes2023.035\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Clinical characteristics and outcome in COVID-19 with brucellosis patients has not been well demonstrated, we tried to analyze clinical outcome in local and literature COVID-19 cases with brucellosis before and after recovery.</p></div><div><h3>Methods</h3><p>We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15, 2020 to April 29, 2022. Demographics, epidemiological, clinical symptoms, radiological and laboratory data, treatment medicines and outcomes, and follow up were analyzed, and findings of a systematic review were demonstrated.</p></div><div><h3>Results</h3><p>A total of four COVID-19 with brucellosis patients were included. One patient had active brucellosis before covid and 3 patients had nonactive brucellosis before brucellosis. The median age was 54.5 years, and all were males (100.0%). Two cases (50.0%) were moderate, and one was mild and asymptomatic, respectively. Three cases (75.0%) had at least one comorbidity (brucellosis excluded). All 4 patients were found in COVID-19 nucleic acid screening. Case C and D had only headache and fever on admission, respectively. Four cases were treated with Traditional Chinese medicine, western medicines for three cases, no adverse reaction occurred during hospitalization. All patients were cured and discharged. Moreover, one case (25.0%) had still active brucellosis without re-positive COVID-19, and other three cases (75.0%) have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after recovery. Conducting the literature review, two similar cases have been reported in two case reports, and were both recovered, whereas, no data of follow up after recovery.</p></div><div><h3>Conclusion</h3><p>These cases indicate that COVID-19 patients with brucellosis had favorable outcome before and after recovery. 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Treatment Outcomes in COVID-19 Patients with Brucellosis: Case Series in Heilongjiang and Systematic Review of Literature
Objective
Clinical characteristics and outcome in COVID-19 with brucellosis patients has not been well demonstrated, we tried to analyze clinical outcome in local and literature COVID-19 cases with brucellosis before and after recovery.
Methods
We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15, 2020 to April 29, 2022. Demographics, epidemiological, clinical symptoms, radiological and laboratory data, treatment medicines and outcomes, and follow up were analyzed, and findings of a systematic review were demonstrated.
Results
A total of four COVID-19 with brucellosis patients were included. One patient had active brucellosis before covid and 3 patients had nonactive brucellosis before brucellosis. The median age was 54.5 years, and all were males (100.0%). Two cases (50.0%) were moderate, and one was mild and asymptomatic, respectively. Three cases (75.0%) had at least one comorbidity (brucellosis excluded). All 4 patients were found in COVID-19 nucleic acid screening. Case C and D had only headache and fever on admission, respectively. Four cases were treated with Traditional Chinese medicine, western medicines for three cases, no adverse reaction occurred during hospitalization. All patients were cured and discharged. Moreover, one case (25.0%) had still active brucellosis without re-positive COVID-19, and other three cases (75.0%) have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after recovery. Conducting the literature review, two similar cases have been reported in two case reports, and were both recovered, whereas, no data of follow up after recovery.
Conclusion
These cases indicate that COVID-19 patients with brucellosis had favorable outcome before and after recovery. More clinical studies should be conducted to confirm our findings.
期刊介绍：
Biomedical and Environmental Sciences (BES) is a peer-reviewed journal jointly established by the Chinese Center for Disease Control and Prevention (China CDC) and the Coulston International Corporation (CIC), USA in 1988, and is published monthly by Elsevier. It is indexed by SCI, PubMed, and CA.
Topics covered by BES include infectious disease prevention, chronic and non-communicable disease prevention, disease control based on preventive medicine, and public health theories. It also focuses on the health impacts of environmental factors in people''s daily lives and work, including air quality, occupational hazards, and radiation hazards.
Article types considered for publication include original articles, letters to the editor, reviews, research highlights, and policy forum.
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