黑色素瘤和肥大细胞：一种不明确的关系。

IF 1.5 4区医学 Q3 DERMATOLOGY

Melanoma Research Pub Date : 2024-02-01 Epub Date: 2023-11-02 DOI:10.1097/CMR.0000000000000932

Lisa M Kohl, Tina L Sumpter

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引用次数: 0

摘要

肥大细胞在包括黑色素瘤在内的多种肿瘤中积累。虽然MCs在感染和过敏性炎症中是免疫的有效启动剂，但MCs在抗黑色素瘤免疫中的作用尚不清楚。MCs具有释放肿瘤细胞因子和蛋白酶、激活抗原呈递细胞和促进抗肿瘤适应性免疫的潜力。然而，在免疫抑制肿瘤微环境（TME）中，MC激活可能促进血管生成并促进肿瘤生长。在这篇综述中，讨论了MC和黑色素瘤之间的关系，重点是TME对MC激活的影响。

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Melanomas and mast cells: an ambiguous relationship.

Mast cells (MCs) accumulate in a broad range of tumors, including melanomas. While MCs are potent initiators of immunity in infection, and in allergic inflammation, the function of MCs in anti-melanoma immunity is unclear. MCs have the potential to release tumoricidal cytokines and proteases, to activate antigen-presenting cells and to promote anti-tumor adaptive immunity. However, within the immunosuppressive tumor microenvironment (TME), MC activation may promote angiogenesis and contribute to tumor growth. In this review, the relationship between MCs and melanomas is discussed with a focus on the impact of the TME on MC activation.

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来源期刊

Melanoma Research 医学-皮肤病学

CiteScore

3.40

自引率

4.50%

发文量

139

审稿时长

6-12 weeks

期刊介绍： Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.